Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V127032-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $171.90 | |
V127032-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $274.90 | |
V127032-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $686.90 | |
V127032-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,053.90 |
Synonyms | HY-17418 | Vinblastinum [INN-Latin] | VINCRISTINE SULFATE IMPURITY H [EP IMPURITY] | cid_5388983 | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadec |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. Thi |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of tubulin beta class I |
Product Description | Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate |
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INCHI | InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1 |
InChi Key | JXLYSJRDGCGARV-CFWMRBGOSA-N |
Canonical SMILES | CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O |
Isomeric SMILES | CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O |
PubChem CID | 13342 |
Molecular Weight | 810.97 |
DrugBank Ligand | DB00570 |
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PubChem CID | 13342 |
CAS Registry No. | 865-21-4 |
ChEMBL Ligand | CHEMBL159 |
Wikipedia | Vinblastine |
ChEBI | CHEBI:27375 |
RCSB PDB Ligand | VLB |
PEP | vinblastine |
DrugCentral Ligand | 2823 |
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Solubility | 25°C: DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL |
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1. Ziming Zheng, Xianglin Pan, Haoyu Wang, Zhijing Wu, Mitchell A. Sullivan, Yuxuan Liu, Junxi Liu, Kaiping Wang, Yu Zhang. (2021) Mechanism of Lentinan Intestinal Absorption: Clathrin-Mediated Endocytosis and Macropinocytosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (26): (7344–7352). [PMID:34132531] [10.1021/acs.jafc.1c00349] |
1. Ziming Zheng, Xianglin Pan, Haoyu Wang, Zhijing Wu, Mitchell A. Sullivan, Yuxuan Liu, Junxi Liu, Kaiping Wang, Yu Zhang. (2021) Mechanism of Lentinan Intestinal Absorption: Clathrin-Mediated Endocytosis and Macropinocytosis. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 69 (26): (7344–7352). [PMID:34132531] [10.1021/acs.jafc.1c00349] |