Vinblastine - 98%, high purity , CAS No.865-21-4, Inhibitor of tubulin beta class I

Item Number

V127032

Grouped product items
SKU	Size	Availability	Price
V127032-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$171.90
V127032-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$274.90
V127032-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$686.90
V127032-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,053.90

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Basic Description

Synonyms	vinblastine\|Vinblastin\|Vincaleucoblastin\|865-21-4\|Vincaleukoblastine\|Vinblastina\|Vincoblastine\|Rozevin\|Nincaluicolflastine\|Vinblastinum\|VR-8\|Vinblastinum [INN-Latin]\|Velban\|CCRIS 9002\|HSDB 3263\|NCI-C04842\|UNII-5V9KLZ54CY\|EINECS 212-734-0\|5V9KLZ54CY\|NSC 47
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. Thi
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of tubulin beta class I
Product Description	Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM.

Names and Identifiers

IUPAC Name	methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate
INCHI	InChI=1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
InChi Key	JXLYSJRDGCGARV-CFWMRBGOSA-N
Canonical SMILES	CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Isomeric SMILES	CC[C@@]1(C[C@H]2C[C@@](C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)[C@]78CCN9[C@H]7[C@@](C=CC9)([C@H]([C@@]([C@@H]8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
PubChem CID	13342
Molecular Weight	810.97