Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V107385-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $39.90 | |
V107385-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $79.90 | |
V107385-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $266.90 | |
V107385-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,059.90 |
Synonyms | HMS2095H04 | C09251 | DTXSID9040134 | Methyl vincaminate | Oxybral | Tox21_111342_1 | Tripervan | Vincamina [DCIT] | VINCAMINE [MART.] | Anasclerol (base) | Equipur | KS-5179 | Vincamina | Cetal retard | HMS3712H04 | methyl (15S,17S,19S)-15-ethyl-17-hydro |
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Specifications & Purity | Moligand™, ≥98% |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor |
Product Description | Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research. |
ALogP | 2.9 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate |
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INCHI | InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1 |
InChi Key | RXPRRQLKFXBCSJ-GIVPXCGWSA-N |
Canonical SMILES | CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O |
Isomeric SMILES | CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4[C@](C2)(C(=O)OC)O |
WGK Germany | 3 |
RTECS | YY8575000 |
PubChem CID | 15376 |
Molecular Weight | 354.44 |
Beilstein | 25(3/4)1252 |
PubChem CID | 15376 |
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ChEBI | CHEBI:9985 |
Wikipedia | Vincamine |
ChEMBL Ligand | CHEMBL1165342 |
CAS Registry No. | 1617-90-9 |
DrugCentral Ligand | 3643 |
GPCRdb Ligand | vincamine |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2402505 | Certificate of Analysis | Mar 09, 2024 | V107385 |
D2402517 | Certificate of Analysis | Mar 09, 2024 | V107385 |
D2402518 | Certificate of Analysis | Mar 09, 2024 | V107385 |
D2402519 | Certificate of Analysis | Mar 09, 2024 | V107385 |
C1813119 | Certificate of Analysis | Jan 27, 2022 | V107385 |
C1813120 | Certificate of Analysis | Jan 27, 2022 | V107385 |
Specific Rotation[α] | 43° (C=1,Pyridine) |
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Melt Point(°C) | 232°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | YY8575000 |
Merck Index | 9983 |
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2. S Caccamese,G Principato. (2000-10-24) Separation of the four pairs of enantiomers of vincamine alkaloids by enantioselective high-performance liquid chromatography.. Journal of chromatography. A, 893 ((1)): (47-54). [PMID:11043586] |
3. S Caccamese,G Principato,R Jokela,A Tolvanen,D Din Belle. (2001-12-18) Chiral HPLC separation and CD spectra of the enantiomers of the alkaloid tacamonine and related compounds.. Chirality, 13 ((10)): (691-693). [PMID:11746802] |
4. Y Kitazawa. (2002-01-23) [Open-angle glaucoma clinical presentation and management].. Nippon Ganka Gakkai zasshi, 105 ((12)): (828-842). [PMID:11802456] |
5. Ying-Ping Juan,Tung-Hu Tsai. (2005-09-01) Measurement and pharmacokinetics of vincamine in rat blood and brain using microdialysis.. Journal of chromatography. A, 1088 ((1-2)): (146-151). [PMID:16130744] |
6. Adám Vas,Balázs Gulyás. (2005-09-15) Eburnamine derivatives and the brain.. Medicinal research reviews, 25 ((6)): (737-757). [PMID:16158388] |
7. Li Di,Edward H Kerns,Hong Chen,Susan L Petusky. (2005-10-20) Development and application of an automated solution stability assay for drug discovery.. Journal of biomolecular screening, 11 ((1)): (40-47). [PMID:16234336] |
8. Dylan B England,Albert Padwa. (2007-07-31) Synthesis of (+/-)-3H-epivincamine via a Rh(II)-triggered cyclization/cycloaddition cascade.. Organic letters, 9 ((17)): (3249-3252). [PMID:17658832] |
9. Amr Mohamed Beltagi. (2008-12-02) Development and validation of an adsorptive stripping voltammetric method for the quantification of vincamine in its formulations and human serum using a Nujol-based carbon paste electrode.. Chemical & pharmaceutical bulletin, 56 ((12)): (1651-1657). [PMID:19043234] |
10. Thomas Sycha,Clemens Vass,Oliver Findl,Peter Bauer,Ilse Groke,Leopold Schmetterer,Hans-Georg Eichler. (2010-02-19) WITHDRAWN: Interventions for normal tension glaucoma.. The Cochrane database of systematic reviews, ((2)(2)): (CD002222-CD002222). [PMID:20166063] |
11. Koichiro Koyama,Yusuke Hirasawa,Takahiro Hosoya,Teh Chin Hoe,Kit-Lam Chan,Hiroshi Morita. (2010-06-26) Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora.. Bioorganic & medicinal chemistry, 18 ((12)): (4415-4421). [PMID:20576577] |
12. Hong Yin,Yu-Hong Sun. (2011-02-15) Vincamine-producing endophytic fungus isolated from Vinca minor.. Phytomedicine : international journal of phytotherapy and phytopharmacology, 18 ((8-9)): (802-805). [PMID:21315568] |
13. Entai Hou,Yingjuan Wang,Duowei Li,Na Li,Hongdong Chen,Huaiyu Bu. (2011-07-19) [Tissue culture of Vinca minor and determination of vincamine].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36 ((7)): (823-827). [PMID:21761716] |
14. Dritan Hasa,Beatrice Perissutti,Cinzia Cepek,Sunil Bhardwaj,Elvio Carlino,Mario Grassi,Sergio Invernizzi,Dario Voinovich. (2012-11-29) Drug salt formation via mechanochemistry: the case study of vincamine.. Molecular pharmaceutics, 10 ((1)): (211-224). [PMID:23186380] |
15. Amir Akhgari,Into Laakso,Tuulikki Seppänen-Laakso,Teijo Yrjönen,Heikki Vuorela,Kirsi-Marja Oksman-Caldentey,Heiko Rischer. (2015-06-23) Determination of terpenoid indole alkaloids in hairy roots of Rhazya stricta (Apocynaceae) by GC-MS.. Phytochemical analysis : PCA, 26 ((5)): (331-338). [PMID:26095837] |
16. Takashi Matsumoto,Yousuke Matsubara,Yasuharu Mizuhara,Kyoji Sekiguchi,Junichi Koseki,Kazuaki Tsuchiya,Hiroaki Nishimura,Junko Watanabe,Atsushi Kaneko,Kazuya Maemura,Tomohisa Hattori,Yoshio Kase. (2015-10-06) Plasma Pharmacokinetics of Polyphenols in a Traditional Japanese Medicine, Jumihaidokuto, Which Suppresses Propionibacterium acnes-Induced Dermatitis in Rats.. Molecules (Basel, Switzerland), 20 ((10)): (18031-18046). [PMID:26437394] |
17. L Vereczkey. (1985-04-01) Pharmacokinetics and metabolism of vincamine and related compounds.. European journal of drug metabolism and pharmacokinetics, 10 ((2)): (89-103). [PMID:3899662] |
18. Mazák Károly,József Vámos,András Nemes,Akos Rácz,Béla Noszál. (2003-07-02) Lipophilicity of vinpocetine and related compounds characterized by reversed-phase thin-layer chromatography.. Journal of chromatography. A, 996 ((1-2)): (195-203). [PMID:12830921] |
19. T Sycha,C Vass,O Findl,P Bauer,I Groke,L Schmetterer,H Eichler. (2003-10-30) Interventions for normal tension glaucoma.. The Cochrane database of systematic reviews, (4) ((4)): (CD002222-CD002222). [PMID:14583947] |
20. Laurent Bezin,Catherine Ortemann,Michaël Ogier,Bernadette Astier,Jean-François Pujol,Bernard Renaud,Laura Lambas-Señas. (2004-11-30) Enhanced tail pinch-induced activation of catecholamine metabolism in the pericerulean area of RU 24722-treated rats.. Brain research, 1030 ((1)): (1-10). [PMID:15567332] |
21. Mostafa A M Shehata,Mohammad A El Sayed,Mohammad F El Tarras,Mohammad G El Bardicy. (2005-05-24) Stability-indicating methods for determination of vincamine in presence of its degradation product.. Journal of pharmaceutical and biomedical analysis, 38 ((1)): (72-78). [PMID:15907622] |
22. Mohammad G El-Bardicy,Hayam M Lotfy,Mohammad A El-Sayed,Mohammad F El-Tarras. (2008-05-15) Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation.. Journal of AOAC International, 91 ((2)): (299-310). [PMID:18476341] |
23. Yasser Shaker Ibrahim El-Saharty. (2008-05-15) Simultaneous determination of piracetam and vincamine by spectrophotometric and high-performance liquid chromatographic methods.. Journal of AOAC International, 91 ((2)): (311-321). [PMID:18476342] |
24. Abdel-Hasseb A Fayed. (2009-11-11) Brain trace element concentration of rats treated with the plant alkaloid, vincamine.. Biological trace element research, 136 ((3)): (314-319). [PMID:19902161] |
25. K Cambon,R Dos-Santos Coura,L Groc,A Carbon,D Weissmann,J P Changeux,J F Pujol,S Granon. (2010-10-07) Aggressive behavior during social interaction in mice is controlled by the modulation of tyrosine hydroxylase expression in the prefrontal cortex.. Neuroscience, 171 ((3)): (840-851). [PMID:20923695] |
26. Paul E Polak,Sergey Kalinin,David Braun,Anthony Sharp,Shao X Lin,Douglas L Feinstein. (2012-02-01) The vincamine derivative vindeburnol provides benefit in a mouse model of multiple sclerosis: effects on the Locus coeruleus.. Journal of neurochemistry, 121 ((2)): (206-216). [PMID:22288774] |