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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V107535-25mg | 25mg | In stock | $20.90 | |
V107535-100mg | 100mg | In stock | $68.90 | |
V107535-1g | 1g | In stock | $621.90 | |
V107535-5g | 5g | In stock | $2,794.90 | |
V107535-25g | 25g | In stock | $12,575.90 |
Cell-permeable PDE1 inhibitor
Synonyms | vinpocetine|42971-09-5|Cavinton|Ceractin|Apovincaminic acid ethyl ester|Bravinton|Ethyl apovincamin-22-oate|Ultra-Vinca|TCV-3B|RGH 4405|Ethyl (+)-apovincaminate|Vinporal|cis-Apovincaminic acid ethyl ester|RGH-4405|Ethyl apovincaminate|Ethyl (+)-cis-apovin |
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Specifications & Purity | 99% |
Storage Temp | Store at -20°C |
Shipped In | Dry ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of phosphodiesterase 1A;Inhibitor of phosphodiesterase 1C |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488189817 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488189817 |
IUPAC Name | ethyl (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18),16-pentaene-17-carboxylate |
INCHI | InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1 |
InChi Key | DDNCQMVWWZOMLN-IRLDBZIGSA-N |
Canonical SMILES | CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC |
Isomeric SMILES | CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4C(=C2)C(=O)OCC |
WGK Germany | 3 |
RTECS | JW4792000 |
PubChem CID | 443955 |
Molecular Weight | 350.45 |
Reaxy-Rn | 900803 |
CAS Registry No. | 42971-09-5 |
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Wikipedia | Vinpocetine |
ChEMBL Ligand | CHEMBL71752 |
PubChem CID | 443955 |
DrugCentral Ligand | 2828 |
PubChem SID | 488189817 |
Enter Lot Number to search for COA:
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Lot Number | Certificate Type | Date | Item |
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G1213063 | Certificate of Analysis | Apr 10, 2024 | V107535 |
E23081180 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081188 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081213 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081225 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081231 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081235 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081259 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081261 | Certificate of Analysis | Jan 13, 2023 | V107535 |
E23081264 | Certificate of Analysis | Jan 13, 2023 | V107535 |
A2304223 | Certificate of Analysis | Jan 09, 2023 | V107535 |
C2211488 | Certificate of Analysis | May 31, 2022 | V107535 |
C2202222 | Certificate of Analysis | Mar 14, 2022 | V107535 |
Solubility | DMSO : 6.25 mg/mL |
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Sensitivity | Light sensitive. |
Specific Rotation[α] | 118° (C=2,Pyridine) |
Melt Point(°C) | 151 °C |
Pictogram(s) | GHS07 |
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Hazard Statements | H302:Harmful if swallowed |
WGK Germany | 3 |
RTECS | JW4792000 |
Reaxy-Rn | 900803 |
Merck Index | 9991 |
1. Lörincz C, Szász K, Kisfaludy L. (1976) The synthesis of ethyl apovincaminate.. Arzneimittelforschung, 26 (10a): (1907). [PMID:1037211] |
2. Szilágyi G, Nagy Z, Balkay L, Boros I, Emri M, Lehel S, Márián T, Molnár T, Szakáll S, Trón L et al.. (2005) Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: a PET study.. J Neurol Sci, 229-230 (3): (275-84). [PMID:15760651] |
3. Sitges M, Galván E, Nekrassov V. (2005) Vinpocetine blockade of sodium channels inhibits the rise in sodium and calcium induced by 4-aminopyridine in synaptosomes.. Neurochem Int, 46 (7): (533-40). [PMID:15843047] |
4. Hagiwara M, Endo T, Hidaka H. (1984) Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.. Biochem Pharmacol, 33 (3): (453-7). [PMID:6322804] |
5. Truss MC, Uckert S, Stief CG, Forssmann WG, Jonas U. (1996) Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. II. Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro.. Urol Res, 24 (3): (129-34). [PMID:8839479] |