Vitamin K2 , CAS No.863-61-6

1 Citations
Item Number
V140453
Grouped product items
SKUSizeAvailabilityPrice Qty
V140453-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$49.90
V140453-1g
1g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$129.90
V140453-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$509.90

Basic Description

SynonymsAKOS037645019 | MQ-4 | Menaquinone K4 | 2-Methyl-3-tetraprenyl-1,4-naphthoquinone | HY-B2156 | NCGC00183125-01 | 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione | 1,4-Naphthalenedione, 2-methyl-3-((2E,6E,10E
Biochemical and Physiological MechanismsMenatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1I2 Tchem Pregnane X receptor (6667 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MG-63 (795 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SNCA Tchem Alpha-synuclein (10960 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAPGEF3 Tchem Rap guanine nucleotide exchange factor 3 (15528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KPNB1 Tbio Importin subunit beta-1/Snurportin-1 (25097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ggcx Vitamin K-dependent gamma-carboxylase (85 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-22 (3261 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TGR Thioredoxin glutathione reductase (28579 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapt Microtubule-associated protein tau (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pgam5 Serine/threonine-protein phosphatase PGAM5, mitochondrial (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dnm1l Dynamin-1-like protein (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione
INCHI InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+
InChi Key DKHGMERMDICWDU-GHDNBGIDSA-N
Canonical SMILES CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Isomeric SMILES CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
WGK Germany 3
RTECS QL9279500
Alternate CAS 11032-49-8
PubChem CID 5282367
Molecular Weight 444.65

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
L2315547Certificate of AnalysisNov 23, 2023 V140453
L2315548Certificate of AnalysisNov 23, 2023 V140453
L2315549Certificate of AnalysisNov 23, 2023 V140453
C2303165Certificate of AnalysisMay 30, 2022 V140453
F2220205Certificate of AnalysisMay 30, 2022 V140453
F2220207Certificate of AnalysisMay 30, 2022 V140453
F2220208Certificate of AnalysisMay 30, 2022 V140453
J2324009Certificate of AnalysisMay 30, 2022 V140453

Chemical and Physical Properties

SolubilitySoluble in diethyl ether, chloroform, and hexane. Insoluble in water.
Refractive Index1.54
Boil Point(°C)570.6° C
Melt Point(°C)227.73°C

Safety and Hazards(GHS)

WGK Germany 3
RTECS QL9279500

Related Documents

Citations of This Product

1. Jiafeng Wang, Longhui Shao, Xiaoyu Wu, Chun Liu, Su Ni, Ting Dai, Hongwei Liu, Hongbin Zhao.  (2023)  Electrospun sandwich mesh structures loaded with naringenin and vitamin K2 polycaprolactone/gelatin nanofibers synergistically promote bone regeneration.  Materials Today Bio,  23  (26): (100794).  [PMID:37766894]

References

1. Norio Iinuma.  (2005-06-03)  [Vitamin K2 (menatetrenone) and bone quality]..  Clinical calcium,  15  ((6)): (1034-1039).  [PMID:15930719]
2. Takayuki Hosoi.  (2007-11-06)  [Treatment of primary osteoporosis with vitamin K2]..  Clinical calcium,  17  ((11)): (1727-1730).  [PMID:17982193]
3. Yoshitomo Suhara,Yoshihisa Hirota,Kimie Nakagawa,Maya Kamao,Naoko Tsugawa,Toshio Okano.  (2008-01-04)  Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines..  Bioorganic & medicinal chemistry,  16  ((6)): (3108-3117).  [PMID:18171617]
4. Jun Iwamoto,Hideo Matsumoto,Tsuyoshi Takeda.  (2009-06-09)  Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three randomized, controlled trials..  Clinical drug investigation,  29  ((7)): (471-479).  [PMID:19499964]
5. Jun Iwamoto,Hideo Matsumoto,Tsuyoshi Takeda,Yoshihiro Sato,James K Yeh.  (2010-06-18)  Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats..  Calcified tissue international,  87  ((3)): (254-262).  [PMID:20556371]
6. Mariko Ochiai,Ayumu Nakashima,Norihisa Takasugi,Kei Kiribayashi,Toru Kawai,Koji Usui,Kenichiro Shigemoto,Naoki Hamaguchi,Nobuoki Kohno,Noriaki Yorioka.  (2010-08-07)  Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level..  Nephron. Clinical practice,  117  ((1)): (c15-c19).  [PMID:20689320]
7. Yoshihiro Sato.  (2010-09-03)  [Dementia and fracture]..  Clinical calcium,  20  ((9)): (1379-1384).  [PMID:20808046]
8. Kimie Nakagawa,Yoshihisa Hirota,Natsumi Sawada,Naohito Yuge,Masato Watanabe,Yuri Uchino,Naoko Okuda,Yuka Shimomura,Yoshitomo Suhara,Toshio Okano.  (2010-10-19)  Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme..  Nature,  468  ((7320)): (117-121).  [PMID:20953171]
9. Hao Zhang,Iwata Ozaki,Hiroshi Hamajima,Shinji Iwane,Hirokazu Takahashi,Yasunori Kawaguchi,Yuichiro Eguchi,Kyosuke Yamamoto,Toshihiko Mizuta.  (2010-11-27)  Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation..  Oncology reports,  25  ((1)): (159-166).  [PMID:21109972]
10. T Terachi,Y Inoue,N Ashihara,M Kobayashi,K Ando,T Matsui.  (2010-12-21)  Plasma vitamin K concentration in horses supplemented with several vitamin K homologs..  Journal of animal science,  89  ((4)): (1056-1061).  [PMID:21169510]
11. Kazuo Kojima,Masaya Tamano,Takashi Akima,Takashi Hashimoto,Toru Kuniyoshi,Chizu Maeda,Yuichi Majima,Koji Kusano,Toshimitu Murohisa,Makoto Iijima,Hideyuki Hiraishi.  (2011-03-18)  Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis..  Hepato-gastroenterology,  57  ((102-103)): (1264-1267).  [PMID:21410069]
12. Gilbert R Kaats,Harry G Preuss,Harry A Croft,Samuel C Keith,Patti L Keith.  (2011-03-31)  A comparative effectiveness study of bone density changes in women over 40 following three bone health plans containing variations of the same novel plant-sourced calcium..  International journal of medical sciences,  ((3)): (180-191).  [PMID:21448303]
13. I H Baek,W Kang,H Y Yun,S S Lee,K I Kwon.  (2011-05-07)  Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism..  Journal of clinical pharmacy and therapeutics,  36  ((3)): (390-398).  [PMID:21545618]
14. Yoshitomo Suhara,Masato Watanabe,Kimie Nakagawa,Akimori Wada,Yoichi Ito,Kazuyoshi Takeda,Kazuhiko Takahashi,Toshio Okano.  (2011-05-13)  Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists..  Journal of medicinal chemistry,  54  ((12)): (4269-4273).  [PMID:21561094]
15. Yoshitomo Suhara,Masato Watanabe,Sayaka Motoyoshi,Kimie Nakagawa,Akimori Wada,Kazuyoshi Takeda,Kazuhiko Takahashi,Hiroaki Tokiwa,Toshio Okano.  (2011-05-31)  Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K..  Journal of medicinal chemistry,  54  ((13)): (4918-4922).  [PMID:21618996]
16. Akihiko Tsuchida,Takao Itoi,Kazuhiko Kasuya,Yuichi Nagakawa,Minako Suzuki,Takahisa Ikeda,Yoshiaki Suzuki,Tatsuya Aoki,Keisuke Miyazawa.  (2011-06-15)  Chemoprevention of chemically-induced biliary carcinogenesis in hamsters by vitamin K2..  Hepato-gastroenterology,  58  ((106)): (290-297).  [PMID:21661384]
17. Yoshihiro Sato,Yoshiaki Honda,Kazuo Umeno,Norimasa Hayashida,Jun Iwamoto,Tsuyoshi Takeda,Hideo Matsumoto.  (2011-07-23)  The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a randomized controlled trial..  The Kurume medical journal,  57  ((4)): (117-124).  [PMID:21778673]
18. Sherry M Farley,Scott W Leonard,Edwin M Labut,Hannah F Raines,David J Card,Dominic J Harrington,Debbie J Mustacich,Maret G Traber.  (2012-06-19)  Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone..  Molecular nutrition & food research,  56  ((6)): (912-922).  [PMID:22707266]
19. Pornpimol Rianthavorn,Kantima Pisutikul,Tawatchai Deekajorndech,Supatporn Tepmongkol,Kanya Suphapeetiporn.  (2012-07-10)  Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone..  Journal of pediatric endocrinology & metabolism : JPEM,  25  ((3-4)): (307-312).  [PMID:22768661]
20. Jun Iwamoto,Yoshihiro Sato.  (2013-01-26)  Menatetrenone for the treatment of osteoporosis..  Expert opinion on pharmacotherapy,  14  ((4)): (449-458).  [PMID:23346882]
21. Fumiaki Hanzawa,Saki Nomura,Eri Sakuma,Tomono Uchida,Saiko Ikeda.  (2013-05-24)  Dietary sesame seed and its lignan, sesamin, increase tocopherol and phylloquinone concentrations in male rats..  The Journal of nutrition,  143  ((7)): (1067-1073).  [PMID:23700348]
22. Yoshihisa Hirota,Naoko Tsugawa,Kimie Nakagawa,Yoshitomo Suhara,Kiyoshi Tanaka,Yuri Uchino,Atsuko Takeuchi,Natsumi Sawada,Maya Kamao,Akimori Wada,Takashi Okitsu,Toshio Okano.  (2013-10-03)  Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats..  The Journal of biological chemistry,  288  ((46)): (33071-33080).  [PMID:24085302]
23. Katheryne Z Edson,Bhagwat Prasad,Jashvant D Unadkat,Yoshitomo Suhara,Toshio Okano,F Peter Guengerich,Allan E Rettie.  (2013-10-22)  Cytochrome P450-dependent catabolism of vitamin K: ω-hydroxylation catalyzed by human CYP4F2 and CYP4F11..  Biochemistry,  52  ((46)): (8276-8285).  [PMID:24138531]
24. Tomohiro Shimizu,Masahiko Takahata,Yusuke Kameda,Hiroki Hamano,Teppei Ito,Hiromi Kimura-Suda,Masahiro Todoh,Shigeru Tadano,Norimasa Iwasaki.  (2014-04-16)  Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair..  Bone,  64  (95-101).  [PMID:24731926]
25. Y F Liao,Y Wang,Y Huang,S F Zha,J J Liu,Z K Wang,Y P Yin,Y F Liao,Y Wang.  (2015-03-17)  ISOLATION AND FUNCTIONAL ANALYSIS OF McMenA, A GENE ENCODING A 1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE IN Mylabris cichorii..  Archives of insect biochemistry and physiology,  89  ((3)): (127-137).  [PMID:25772016]
26. Pinkesh G Sutariya,Alok Pandya,Anand Lodha,Shobhana K Menon.  (2015-11-26)  A simple and rapid creatinine sensing via DLS selectivity, using calix[4]arene thiol functionalized gold nanoparticles..  Talanta,  147  (590-597).  [PMID:26592650]
27. Sarah Nicolai,Marcin Wegrecki,Tan-Yun Cheng,Elvire A Bourgeois,Rachel N Cotton,Jacob A Mayfield,Gwennaëlle C Monnot,Jérôme Le Nours,Ildiko Van Rhijn,Jamie Rossjohn,D Branch Moody,Annemieke de Jong.  (2020-01-05)  Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products..  Science immunology,  ((43)):   [PMID:31901073]
28. Dong-Jae Jun,Marc M Schumacher,Seonghwan Hwang,Lisa N Kinch,Nick V Grishin,Russell A DeBose-Boyd.  (2020-03-20)  Schnyder corneal dystrophy-associated UBIAD1 is defective in MK-4 synthesis and resists autophagy-mediated degradation..  Journal of lipid research,  61  ((5)): (746-757).  [PMID:32188638]
29. Cathrine Arnason Bøe,Helge Holo.  (2020-04-08)  Engineering Lactococcus lactis for Increased Vitamin K2 Production..  Frontiers in bioengineering and biotechnology,  (191-191).  [PMID:32258010]
30. Fengsen Duan,Chunlei Mei,Luhao Yang,Junyan Zheng,Huiai Lu,Yanzhi Xia,Stacy Hsu,Huageng Liang,Ling Hong.  (2020-05-10)  Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells..  Scientific reports,  10  ((1)): (7714-7714).  [PMID:32382009]
31. Jonna Weisell,Anna-Kaisa Ruotsalainen,Juha Näpänkangas,Matti Jauhiainen,Jaana Rysä.  (2021-02-06)  Menaquinone 4 increases plasma lipid levels in hypercholesterolemic mice..  Scientific reports,  11  ((1)): (3014-3014).  [PMID:33542347]
32. Hans B Smith,Tin Lok Li,Man Kit Liao,Grischa Y Chen,Zhihong Guo,John-Demian Sauer.  (2021-02-24)  Listeria monocytogenes MenI Encodes a DHNA-CoA Thioesterase Necessary for Menaquinone Biosynthesis, Cytosolic Survival, and Virulence..  Infection and immunity,  89  ((5)):   [PMID:33619030]
33. Xi Gu,Ing-Gin Chen,Scott A Harding,Batbayar Nyamdari,Maria A Ortega,Kristen Clermont,James H Westwood,Chung-Jui Tsai.  (2021-04-02)  Plasma membrane phylloquinone biosynthesis in nonphotosynthetic parasitic plants..  Plant physiology,  185  ((4)): (1443-1456).  [PMID:33793953]
34. Natsuko Sogabe,Rieko Maruyama,Otto Baba,Takayuki Hosoi,Masae Goseki-Sone.  (2011-02-08)  Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats..  Bone,  48  ((5)): (1036-1042).  [PMID:21295170]
35. Thawee Songpatanasilp,La-or Chailurkit,Suwannee Chantprasertyothin,Boonsong Ongphiphadhanakul,Nimit Taechakraichana.  (2011-02-24)  Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 (menatetrenone) among postmenopausal Thai women..  Journal of bone and mineral metabolism,  29  ((5)): (606-614).  [PMID:21344298]
36. Makoto Otsuka,Ryuhei Hirano.  (2011-04-05)  Bone cell activity responsive drug release from biodegradable apatite/collagen nano-composite cements--in vitro dissolution medium responsive vitamin K2 release..  Colloids and surfaces. B, Biointerfaces,  85  ((2)): (338-342).  [PMID:21458964]
37. Asagi Ito,Hitoshi Shirakawa,Naofumi Takumi,Yoshihiko Minegishi,Ai Ohashi,Zakir H Howlader,Yusuke Ohsaki,Toshiro Sato,Tomoko Goto,Michio Komai.  (2011-09-15)  Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells..  Lipids in health and disease,  10  (158-158).  [PMID:21914161]
38. Yoshitomo Suhara,Norika Hanada,Takashi Okitsu,Miho Sakai,Masato Watanabe,Kimie Nakagawa,Akimori Wada,Kazuyoshi Takeda,Kazuhiko Takahashi,Hiroaki Tokiwa,Toshio Okano.  (2012-01-19)  Structure-activity relationship of novel menaquinone-4 analogues: modification of the side chain affects their biological activities..  Journal of medicinal chemistry,  55  ((4)): (1553-1558).  [PMID:22250752]
39. Ala Al Rajabi,Sarah L Booth,James W Peterson,Sang Woon Choi,John W Suttie,M Kyla Shea,Benchun Miao,Michael A Grusak,Xueyan Fu.  (2012-03-23)  Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-4 among Fischer 344 male rats..  The Journal of nutrition,  142  ((5)): (841-845).  [PMID:22437559]
40. Toshiro Sato,Leon J Schurgers,Kazuhiro Uenishi.  (2012-11-13)  Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women..  Nutrition journal,  11  (93-93).  [PMID:23140417]
41. Michael L Nickerson,Allen D Bosley,Jayne S Weiss,Brittany N Kostiha,Yoshihisa Hirota,Wolfgang Brandt,Dominic Esposito,Shigeru Kinoshita,Ludger Wessjohann,Scott G Morham,Thorkell Andresson,Howard S Kruth,Toshio Okano,Michael Dean.  (2012-11-22)  The UBIAD1 prenyltransferase links menaquinone-4 [corrected] synthesis to cholesterol metabolic enzymes..  Human mutation,  34  ((2)): (317-329).  [PMID:23169578]
42. Mitsuru Ishizuka,Keiichi Kubota,Mitsugi Shimoda,Junji Kita,Masato Kato,Kyung Hwa Park,Takayuki Shiraki.  (2012-12-12)  Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial..  Anticancer research,  32  ((12)): (5415-5420).  [PMID:23225445]
43. Carla A F Portela,Kathleen F Smart,Sergey Tumanov,Gregory M Cook,Silas G Villas-Bôas.  (2014-03-25)  Global metabolic response of Enterococcus faecalis to oxygen..  Journal of bacteriology,  196  ((11)): (2012-2022).  [PMID:24659768]
44. Wei-Jie Wu,Hwa-Young Lee,Geum-Hwa Lee,Han-Jung Chae,Byung-Yong Ahn.  (2014-09-27)  The antiosteoporotic effects of Cheonggukjang containing vitamin k2 (menaquinone-7) in ovariectomized rats..  Journal of medicinal food,  17  ((12)): (1298-1305).  [PMID:25259841]
45. Erin D Lew,Jennifer Oh,Patrick G Burrola,Irit Lax,Anna Zagórska,Paqui G Través,Joseph Schlessinger,Greg Lemke.  (2014-09-30)  Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities..  eLife,    [PMID:25265470]
46. Lei Wang,Sebastian S DeMarco,JianMing Chen,Charles M Phillips,Lance C Bridges.  (2015-04-01)  Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma..  The Journal of investigative dermatology,  135  ((8)): (2102-2108).  [PMID:25826424]
47. Jiafeng Wang, Longhui Shao, Xiaoyu Wu, Chun Liu, Su Ni, Ting Dai, Hongwei Liu, Hongbin Zhao.  (2023)  Electrospun sandwich mesh structures loaded with naringenin and vitamin K2 polycaprolactone/gelatin nanofibers synergistically promote bone regeneration.  Materials Today Bio,  23  (26): (100794).  [PMID:37766894]

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