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SKU | Size | Availability | Price | Qty |
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V423649-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $132.90 |
Antioxidant agent. Potent glucosidase inhibitor. HIF-1 α inhibitor.
Synonyms | Vitexin | 3681-93-4 | Apigenin 8-C-glucoside | 8-beta-D-Glucopyranosyl-apigenin | EINECS 222-963-8 | UNII-9VP70K75OK | ORIENTOSIDE | VITEXINA | VITEXINE | 9VP70K75OK | Apigenin-8-C-glucoside | CHEBI:16954 | Flavone, 8-D-glucosyl-4',5,7-trihydroxy- | 4H-1-Benzopyran-4-one, 5,7-dihy |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Antioxidant agent. Potent glucosidase inhibitor (IC 50 = 48 nM). HIF-1 α inhibitor. Inhibits TNF-α, IL-1β, IL-6, and IL-33 production. Shows antinociceptive, anti-inflammatory, and antioxidant effects in vivo. |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Vitexin is a naturally-occuring flavonoid and lignan compound that is identified in various plant sources. Vitexin is demonstrated to produce antioxidant effects in accord with other flavonoid compounds. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one |
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INCHI | InChI=1S/C21H20O10/c22-7-14-17(27)18(28)19(29)21(31-14)16-11(25)5-10(24)15-12(26)6-13(30-20(15)16)8-1-3-9(23)4-2-8/h1-6,14,17-19,21-25,27-29H,7H2/t14-,17-,18+,19-,21+/m1/s1 |
InChi Key | SGEWCQFRYRRZDC-VPRICQMDSA-N |
Canonical SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4C(C(C(C(O4)CO)O)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O |
WGK Germany | 3 |
PubChem CID | 5280441 |
Molecular Weight | 432.38 |
Beilstein | 67796 |
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Sensitivity | Moisture sensitive |
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WGK Germany | 3 |
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1. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722] |
2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
3. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Multispectroscopic and computational evaluation of the binding of flavonoids with bovine serum albumin in the presence of Cu2+. FOOD CHEMISTRY, 385 (132656). [PMID:35279499] [10.1016/j.foodchem.2022.132656] |
4. Ying Li, Bo Chen, Hai-Yan Cao, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang. (2021) Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaf extract in vitro and in vivo. Food & Function, 12 (16): (7440-7447). [PMID:34195734] [10.1039/D1FO01168E] |
5. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang. (2020) The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract. Foods, 9 (12): (1816). [PMID:33297502] [10.3390/foods9121816] |
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
8. Xiaoqin Wang, Wencong Jia, Guoyin Lai, Lijuan Wang, María del Mar Contreras, Daomao Yang. (2020) Extraction for profiling free and bound phenolic compounds in tea seed oil by deep eutectic solvents. JOURNAL OF FOOD SCIENCE, 85 (5): (1450-1461). [PMID:32249418] [10.1111/1750-3841.15019] |
9. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, 32 (296). [PMID:] [10.1016/j.jff.2017.03.003] |
10. Lingyi Liu, Meirong Pang, Ying Zhang. (2015) Lipase-catalyzed regioselective synthesis of flavone C-glucosides esters and high-efficiency oil-soluble antioxidant of bamboo leaves (eAOB-o). EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 117 (10): (1636-1646). [PMID:] [10.1002/ejlt.201400541] |
11. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044] |
12. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang. (2018-05-09) Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins.. Molecules (Basel, Switzerland), 23 ((5)): [PMID:29738446] |
1. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] [10.1016/j.resconrec.2022.106722] |
2. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Insights from multi-spectroscopic analysis and molecular modeling to understand the structure–affinity relationship and the interaction mechanism of flavonoids with gliadin. Food & Function, 13 (9): (5061-5074). [PMID:35404372] [10.1039/D1FO03816H] |
3. Jie Zhao, Lin Huang, Renjie Li, Zhuangwei Zhang, Jin Chen, Hongjin Tang. (2022) Multispectroscopic and computational evaluation of the binding of flavonoids with bovine serum albumin in the presence of Cu2+. FOOD CHEMISTRY, 385 (132656). [PMID:35279499] [10.1016/j.foodchem.2022.132656] |
4. Ying Li, Bo Chen, Hai-Yan Cao, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang. (2021) Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaf extract in vitro and in vivo. Food & Function, 12 (16): (7440-7447). [PMID:34195734] [10.1039/D1FO01168E] |
5. Liuying Zhu, Wenting Li, Zeyuan Deng, Hongyan Li, Bing Zhang. (2020) The Composition and Antioxidant Activity of Bound Phenolics in Three Legumes, and Their Metabolism and Bioaccessibility of Gastrointestinal Tract. Foods, 9 (12): (1816). [PMID:33297502] [10.3390/foods9121816] |
6. Hongjin Tang, Lin Huang, Dongsheng Zhao, Chunyong Sun, Ping Song. (2020) Interaction mechanism of flavonoids on bovine serum albumin: Insights from molecular property-binding affinity relationship. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 239 (118519). [PMID:32480277] [10.1016/j.saa.2020.118519] |
7. Jie Zhao, Lin Huang, Chunyong Sun, Dongsheng Zhao, Hongjin Tang. (2020) Studies on the structure-activity relationship and interaction mechanism of flavonoids and xanthine oxidase through enzyme kinetics, spectroscopy methods and molecular simulations. FOOD CHEMISTRY, 323 (126807). [PMID:32330646] [10.1016/j.foodchem.2020.126807] |
8. Xiaoqin Wang, Wencong Jia, Guoyin Lai, Lijuan Wang, María del Mar Contreras, Daomao Yang. (2020) Extraction for profiling free and bound phenolic compounds in tea seed oil by deep eutectic solvents. JOURNAL OF FOOD SCIENCE, 85 (5): (1450-1461). [PMID:32249418] [10.1111/1750-3841.15019] |
9. Han Peng, Wenting Li, Hongyan Li, Zeyuan Deng, Bing Zhang. (2017) Extractable and non-extractable bound phenolic compositions and their antioxidant properties in seed coat and cotyledon of black soybean (Glycinemax (L.) merr). Journal of Functional Foods, 32 (296). [PMID:] [10.1016/j.jff.2017.03.003] |
10. Lingyi Liu, Meirong Pang, Ying Zhang. (2015) Lipase-catalyzed regioselective synthesis of flavone C-glucosides esters and high-efficiency oil-soluble antioxidant of bamboo leaves (eAOB-o). EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 117 (10): (1636-1646). [PMID:] [10.1002/ejlt.201400541] |
11. Hui Cao,Xiaojuan Liu,Nataša Poklar Ulrih,Pradeep K Sengupta,Jianbo Xiao. (2018-09-04) Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.. Food chemistry, 270 (257-263). [PMID:30174044] |
12. Shi Shen,Jingbo Wang,Qin Zhuo,Xi Chen,Tingting Liu,Shuang-Qing Zhang. (2018-05-09) Quantitative and Discriminative Evaluation of Contents of Phenolic and Flavonoid and Antioxidant Competence for Chinese Honeys from Different Botanical Origins.. Molecules (Basel, Switzerland), 23 ((5)): [PMID:29738446] |