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Vodobatinib (K0706) - 98%, high purity , CAS No.1388803-90-4, Inhibitor of ABL proto-oncogene 1; non-receptor tyrosine kinase
Basic Description Synonyms Vodobatinib | 1388803-90-4 | SCO-088 | K0706 | K-0706 | Vodobatinib [USAN] | N8Q12KU2SW | Vodobatinib (USAN) | 2-chloro-6-methyl-N'-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide | 2-Chloro-6-methyl-N'-(4-methyl-3-(quinolin-3-ylethynyl)benzoyl)benzohydrazide | 4- Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of ABL proto-oncogene 1; non-receptor tyrosine kinase Product Description Product description：
Vodobatinib (K0706) is a potent, third generation and orally active Bcr-Abl1 tyrosine kinase inhibitor with an IC50 of 7 nM. Vodobatinib exhibits activity against most BCR-ABL1 point mutants, and has no activity against BCR-ABL1T315I. Vodobatinib can be used for chronic myeloid leukemia (CML) research
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-chloro-6-methyl-N'-[4-methyl-3-(2-quinolin-3-ylethynyl)benzoyl]benzohydrazide INCHI InChI=1S/C27H20ClN3O2/c1-17-10-12-22(26(32)30-31-27(33)25-18(2)6-5-8-23(25)28)15-20(17)13-11-19-14-21-7-3-4-9-24(21)29-16-19/h3-10,12,14-16H,1-2H3,(H,30,32)(H,31,33) InChi Key ZQOBVMHBVWNVBG-UHFFFAOYSA-N Canonical SMILES CC1=C(C(=CC=C1)Cl)C(=O)NNC(=O)C2=CC(=C(C=C2)C)C#CC3=CC4=CC=CC=C4N=C3 Isomeric SMILES CC1=C(C(=CC=C1)Cl)C(=O)NNC(=O)C2=CC(=C(C=C2)C)C#CC3=CC4=CC=CC=C4N=C3 PubChem CID 89884852 Molecular Weight 453.9
Chemical and Physical Properties Solubility DMSO : 125 mg/mL (275.38 mM; Need ultrasonic)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P264: Wash hands [and …] thoroughly after handling.
P337+P313: IF eye irritation persists: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P332+P313: IF SKIN irritation occurs: Get medical advice/attention.
References 1. Antelope O, Vellore NA, Pomicter AD, Patel AB, Van Scoyk A, Clair PM, Deininger MW, O'Hare T. (2019) BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia.. Exp Hematol, 77 (3): (36-40.e2). [PMID:31493432 ]
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