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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V426161-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $52.90 |
α-glucosidase inhibitor
Synonyms | voglibose | 83480-29-9 | Basen | Glustat | AO-128 | AO 128 | A-71100 | (1S,2S,3R,4S,5S)-5-((1,3-dihydroxypropan-2-yl)amino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetraol | CHEMBL476960 | DTXSID2021442 | S77P977AG8 | 3,4-Dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-C-(h |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Orally activeα-glucosidase inhibitor (IC50values are 3.9 and 6.4 nM at sucrase and maltase respectively). Increases Glukagon-like peptide 1 (GLP-1) secretion and decreases food consumption inob/obmice, and reduces plasma concentrations of glucose, triglyc |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Product Description | Voglibose is an α-glucosidase inhibitor, similar to acarbose and miglitol, used for lowering post-prandial hyperglycemia (PPHG) in people with diabetes mellitus. Voglibose is used to study it benefits as a protectant against ischemia-reperfusion injury through Glukagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol |
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INCHI | InChI=1S/C10H21NO7/c12-2-5(3-13)11-6-1-10(18,4-14)9(17)8(16)7(6)15/h5-9,11-18H,1-4H2/t6-,7-,8+,9-,10-/m0/s1 |
InChi Key | FZNCGRZWXLXZSZ-CIQUZCHMSA-N |
Canonical SMILES | C1C(C(C(C(C1(CO)O)O)O)O)NC(CO)CO |
Isomeric SMILES | C1[C@@H]([C@@H]([C@H]([C@@H]([C@]1(CO)O)O)O)O)NC(CO)CO |
WGK Germany | 3 |
RTECS | NM7524600 |
PubChem CID | 444020 |
Molecular Weight | 267.28 |
Reaxy-Rn | 5430708 |
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Sensitivity | Heat sensitive |
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Specific Rotation[α] | 46°(C=1,0.1mol/L HCL) |
Melt Point(°C) | 165°C |
WGK Germany | 3 |
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RTECS | NM7524600 |
Reaxy-Rn | 5430708 |
Merck Index | 10029 |