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Vorasidenib (AG-881) - 98%, high purity , IDH1/IDH2 inhibitor, CAS No.1644545-52-7, IDH1/IDH2 inhibitor

Moligand™

≥98%

CAS#: 1644545-52-7
Formula: C₁₄H₁₃ClF₆N₆
Molecular Weight: 414.74
PubChem CID: 117817422

Item Number

V305105

Grouped product items
SKU	Size	Availability	Price
V305105-1mg	1mg	In stock	$35.90
V305105-5mg	5mg	In stock	$147.90
V305105-10mg	10mg	In stock	$246.90
V305105-25mg	25mg	In stock	$555.90
V305105-50mg	50mg	In stock	$741.90
V305105-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,088.90

View related series

Isocitrate Dehydrogenase (IDH) isocitrate dehydrogenase (NADP(+)) 1 Inhibitor isocitrate dehydrogenase (NADP(+)) 2 Inhibitor Metabolic Enzyme/Protease

Basic Description

Synonyms	6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine \| AG 881 [WHO-DD] \| C73178 \| Vorasidenib [INN] \| 6-(6-chloropyridin-2-yl)-N~2~,N~4~-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine \| BDBM2799
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	IDH1/IDH2 inhibitor

Associated Targets(Human)

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (4 Activities)

Discover Target: IDH1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IDH2 Tclin Isocitrate dehydrogenase [NADP], mitochondrial (2 Activities)

Discover Target: IDH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HT-1080 (3966 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-87 MG (3946 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)

Discover Target: IDH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine
INCHI	InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1
InChi Key	QCZAWDGAVJMPTA-RNFRBKRXSA-N
Canonical SMILES	CC(C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)NC(C)C(F)(F)F
Isomeric SMILES	C[C@H](C(F)(F)F)NC1=NC(=NC(=N1)C2=NC(=CC=C2)Cl)N[C@H](C)C(F)(F)F
PubChem CID	117817422
Molecular Weight	414.74

CAS Registry No.

PubChem CID

BindingDB Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
A2219524	Certificate of Analysis	Nov 04, 2024	V305105
A2219525	Certificate of Analysis	Nov 04, 2024	V305105
A2219526	Certificate of Analysis	Nov 04, 2024	V305105
A2219683	Certificate of Analysis	Nov 04, 2024	V305105
A2219685	Certificate of Analysis	Nov 04, 2024	V305105
A2219686	Certificate of Analysis	Nov 04, 2024	V305105

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

References

1. Boddu P, Borthakur G. (2017) Therapeutic targeting of isocitrate dehydrogenase mutant AML.. Expert Opin Investig Drugs, 26 (5): (525-530). [PMID:28388242] [10.1021/op500134e]
2. Ma R, Yun CH. (2018) Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2.. Biochem Biophys Res Commun, 503 (4): (2912-2917). [PMID:30131249] [10.1021/op500134e]
3. Karpel-Massler G, Nguyen TTT, Shang E, Siegelin MD. (2019) Novel IDH1-Targeted Glioma Therapies.. CNS Drugs, 33 (12): (1155-1166). [PMID:31768950] [10.1021/op500134e]
4. Konteatis Z, Artin E, Nicolay B, Straley K, Padyana AK, Jin L, Chen Y, Narayaraswamy R, Tong S, Wang F et al.. (2020) Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma.. ACS Med Chem Lett, 11 (2): (101-107). [PMID:32071674] [10.1021/acsmedchemlett.9b00509]

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Vorasidenib (AG-881) - 98%, high purity , IDH1/IDH2 inhibitor, CAS No.1644545-52-7, IDH1/IDH2 inhibitor

Basic Description

Product Properties

Associated Targets(Human)

Mechanisms of Action