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Vortioxetine (Lu AA21004) HBr - ≥98%, high purity , Serotonin 3a (5-HT3a) receptor antagonist, CAS No.960203-27-4, Serotonin 3a (5-HT3a) receptor antagonist

≥98%

CAS#: 960203-27-4
Formula: C₁₈H₂₂N₂S·HBr
Molecular Weight: 379.36
PubChem CID: 56843850
PubChem SID: 488201771

Item Number

V129787

Grouped product items
SKU	Size	Availability	Price
V129787-5mg	5mg	In stock	$11.90
V129787-25mg	25mg	In stock	$48.90
V129787-100mg	100mg	In stock	$162.90
V129787-500mg	500mg	In stock	$489.90

Basic Description

Synonyms	Vortioxetine hydrobromide \| 960203-27-4 \| Vortioxetine HBr \| Brintellix \| Trintellix \| Vortioxetine (Lu AA21004) HBr \| Vortioxetine (hydrobromide) \| UNII-TKS641KOAY \| Lu AA 21004 hydrobromide \| Lu aa21004 hbr \| TKS641KOAY \| Lu-aa21004 hydrobromide \| CHEBI:76015 \| Vortioxetine hydr
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	AGONIST
Mechanism of action	Serotonin 3a (5-HT3a) receptor antagonist
Note	卖完停产，不再备货
Product Description	Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

Associated Targets(Human)

CYP2C8 Tchem Cytochrome P450 2C8 (1492 Activities)

Discover Target: CYP2C8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2E1 Tchem Cytochrome P450 2E1 (2174 Activities)

Discover Target: CYP2E1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2A6 Tchem Cytochrome P450 2A6 (2861 Activities)

Discover Target: CYP2A6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2B6 Tchem Cytochrome P450 2B6 (1338 Activities)

Discover Target: CYP2B6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FMO3 Tbio Dimethylaniline monooxygenase [N-oxide-forming] 3 (9 Activities)

Discover Target: FMO3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488201771
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488201771
IUPAC Name	1-[2-(2,4-dimethylphenyl)sulfanylphenyl]piperazine;hydrobromide
INCHI	InChI=1S/C18H22N2S.BrH/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20;/h3-8,13,19H,9-12H2,1-2H3;1H
InChi Key	VNGRUFUIHGGOOM-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C.Br
Isomeric SMILES	CC1=CC(=C(C=C1)SC2=CC=CC=C2N3CCNCC3)C.Br
PubChem CID	56843850
Molecular Weight	379.36

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
D23211624	Certificate of Analysis	Mar 15, 2023	V129787
D23211630	Certificate of Analysis	Mar 15, 2023	V129787
D23211646	Certificate of Analysis	Mar 15, 2023	V129787
D23211649	Certificate of Analysis	Mar 15, 2023	V129787
D23211661	Certificate of Analysis	Mar 15, 2023	V129787

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H317:May cause an allergic skin reaction H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

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