VRK-IN-1 - 99%, high purity , CAS No.2378855-09-3

Item Number

V647791

Grouped product items
SKU	Size	Availability	Price
V647791-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$139.90
V647791-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$300.90
V647791-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$480.90
V647791-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$950.90
V647791-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,450.90
V647791-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,250.90

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Basic Description

Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1) , with an IC 50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders In Vitro VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a K d of 190 nM. VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 150 nM (VRK1)

Associated Targets(Human)

HeLa (62764 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VRK1 Tbio Serine/threonine-protein kinase VRK1 (258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

VRK2 Tbio Serine/threonine-protein kinase VRK2 (740 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[5-(3,5-difluoro-4-hydroxyphenyl)-6-methylpyridin-3-yl]-2,6-difluorophenol
INCHI	InChI=1S/C18H11F4NO2/c1-8-12(10-5-15(21)18(25)16(22)6-10)2-11(7-23-8)9-3-13(19)17(24)14(20)4-9/h2-7,24-25H,1H3
InChi Key	PMRGRXLXKYUDIH-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F
Isomeric SMILES	CC1=C(C=C(C=N1)C2=CC(=C(C(=C2)F)O)F)C3=CC(=C(C(=C3)F)O)F
PubChem CID	155511407
Molecular Weight	349.28

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Basic Description