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VU 0364770 - ≥98%, high purity , CAS No.61350-00-3, Allosteric modulator of mGlu 4 receptor

Moligand™

≥98%

CAS#: 61350-00-3
Formula: C₁₂H₉ClN₂O
Molecular Weight: 232.67
PubChem CID: 836002

Item Number

V129525

Grouped product items
SKU	Size	Availability	Price
V129525-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$88.90
V129525-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$197.90
V129525-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$315.90
V129525-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$711.90

Positive allosteric modulator of mGlu4receptors

View related series

GPCR/G Protein mGlu4 receptor Allosteric modulator mGluR Neuronal Signaling

Basic Description

Synonyms	HY-100588 \| HMS3884L20 \| VU 0364770 \| N-(3-chloro-phenyl)-pyridine-2-carboxamide \| N-(3-chlorophenyl)pyridine-2-carboxamide \| BK0 \| HB0640 \| SY122460 \| BCP19097 \| VU0364770 \| VU-0364770 \| EX-A1099 \| CCG-266813 \| SW219537-1 \| SCHEMBL2530324 \| GTPL6234 \| N-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Positive allosteric modulator at mGlu4receptors (EC50= 290 nM in mGlu4-expressing HEK 293 cells). Reverses haloperidol-induced catalepsy in rats; prevents attentional deficit and forelimb asymmetry in a rodent model of Parkinson's disease. Exhibits affini
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of mGlu 4 receptor
Note	50mg、250mg、10mg卖完停产，不再备货
Product Description	VU 0364770 is a positive allosteric modulator(PAM) of mGlu4 with EC50 of 1.1 μM, exhibits insignificant activity at 68 other receptors, including other mGlu subtypes. A postitive allosteric modulator of mGluR-4

Associated Targets(Human)

GRM4 Tchem Metabotropic glutamate receptor 4 (2 Activities)

Discover Target: GRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GRM3 Tchem Metabotropic glutamate receptor 3 (732 Activities)

Discover Target: GRM3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM4 Tchem Metabotropic glutamate receptor 4 (2320 Activities)

Discover Target: GRM4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM6 Tchem Metabotropic glutamate receptor 6 (361 Activities)

Discover Target: GRM6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM1 Tchem Metabotropic glutamate receptor 1 (2309 Activities)

Discover Target: GRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GRM5 Tchem Metabotropic glutamate receptor 5 (5733 Activities)

Discover Target: GRM5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Grm2 Metabotropic glutamate receptor 2 (1326 Activities)

Discover Target: Grm2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grm8 Metabotropic glutamate receptor 8 (169 Activities)

Discover Target: Grm8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grm7 Metabotropic glutamate receptor 7 (580 Activities)

Discover Target: Grm7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-(3-chlorophenyl)pyridine-2-carboxamide
INCHI	InChI=1S/C12H9ClN2O/c13-9-4-3-5-10(8-9)15-12(16)11-6-1-2-7-14-11/h1-8H,(H,15,16)
InChi Key	SUYUTNCKIOLMAJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl
Isomeric SMILES	C1=CC=NC(=C1)C(=O)NC2=CC(=CC=C2)Cl
Alternate CAS	61350-00-3
PubChem CID	836002
MeSH Entry Terms	N-(3-chlorophenyl)picolinamide;VU0364770
Molecular Weight	232.67

Certificates

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2 results found

Lot Number	Certificate Type	Date	Item
K2307094	Certificate of Analysis	Jan 16, 2023	V129525
E1712144	Certificate of Analysis	Jan 16, 2023	V129525

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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