VU 0409551 - ≥98%(HPLC), high purity , CAS No.1363281-27-9, Allosteric modulator of mGlu 5 receptor

Item Number
V288400
Grouped product items
SKUSizeAvailabilityPrice Qty
V288400-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$68.90
V288400-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$117.90
V288400-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$256.90
V288400-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$434.90
V288400-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$741.90

Selective positive allosteric modulator of mGlu5receptors and brain penetrant

Basic Description

Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsSelective mGlu5positive allosteric modulator (EC50= 260 nM). Selective for mGlu5over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cogn
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 5 receptor

Associated Targets(Human)

GRM5 Tchem Metabotropic glutamate receptor 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone
INCHI InChI=1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2
InChi Key QUZLMKNNIUSREV-UHFFFAOYSA-N
Canonical SMILES C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F
Isomeric SMILES C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F
PubChem CID 56846694
Molecular Weight 352.36

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
J2422732Certificate of AnalysisJul 29, 2024 V288400
J2422738Certificate of AnalysisJul 29, 2024 V288400
J2422739Certificate of AnalysisJul 29, 2024 V288400
J2422747Certificate of AnalysisJul 29, 2024 V288400
J2422748Certificate of AnalysisJul 29, 2024 V288400
J2422789Certificate of AnalysisJul 29, 2024 V288400
J2422796Certificate of AnalysisJul 29, 2024 V288400
J2422799Certificate of AnalysisJul 29, 2024 V288400
J2422810Certificate of AnalysisJul 29, 2024 V288400

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 35.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 17.62, Max Conc. mM: 50

Safety and Hazards(GHS)

Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

Related Documents

References

1. Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN et al..  (2015)  Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents..  Neuron,  86  (4): (1029-1040).  [PMID:25937172] [10.1021/op500134e]

Solution Calculators