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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V288400-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $68.90 | |
V288400-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $117.90 | |
V288400-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $256.90 | |
V288400-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $434.90 | |
V288400-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $741.90 |
Selective positive allosteric modulator of mGlu5receptors and brain penetrant
Specifications & Purity | Moligand™, ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | Selective mGlu5positive allosteric modulator (EC50= 260 nM). Selective for mGlu5over other mGluR subtypes, as well as 66 other receptors and ion channels. Selectively potentiates mGlu5signaling via Gαq. Exhibits wake-promoting, antipsychotic-like and cogn |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 5 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-[1,3]oxazolo[5,4-c]pyridin-5-yl]methanone |
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INCHI | InChI=1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2 |
InChi Key | QUZLMKNNIUSREV-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F |
Isomeric SMILES | C1CN(CC2=C1N=C(O2)COC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)F |
PubChem CID | 56846694 |
Molecular Weight | 352.36 |
PubChem CID | 56846694 |
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CAS Registry No. | 1363281-27-9 |
GPCRdb Ligand | VU0409551 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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J2422732 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422738 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422739 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422747 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422748 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422789 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422796 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422799 | Certificate of Analysis | Jul 29, 2024 | V288400 |
J2422810 | Certificate of Analysis | Jul 29, 2024 | V288400 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 35.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 17.62, Max Conc. mM: 50 |
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Signal | Warning |
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Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
1. Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN et al.. (2015) Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.. Neuron, 86 (4): (1029-1040). [PMID:25937172] [10.1021/op500134e] |