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VU 0422288 - ≥98%(HPLC), high purity , CAS No.1630936-95-6, Allosteric modulator of mGlu 8 receptor
Selective positive allosteric modulator of group III mGlu receptors
Basic Description Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms Group III mGlu receptor positive allosteric modulator (EC50values are 108, 125 and 146 nM for mGlu4, mGlu8and mGlu7respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ALLOSTERIC MODULATOR Mechanism of action Allosteric modulator of mGlu 8 receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488202331 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202331 IUPAC Name N-[3-chloro-4-(5-chloropyridin-2-yl)oxyphenyl]pyridine-2-carboxamide INCHI InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23) InChi Key MZRLPXFGQKQHST-UHFFFAOYSA-N Canonical SMILES C1=CC=NC(=C1)C(=O)NC2=CC(=C(C=C2)OC3=NC=C(C=C3)Cl)Cl Isomeric SMILES C1=CC=NC(=C1)C(=O)NC2=CC(=C(C=C2)OC3=NC=C(C=C3)Cl)Cl PubChem CID 73058507 Molecular Weight 360.19
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 36.02, Max Conc. mM: 100
Safety and Hazards(GHS) RIDADR NONHforallmodesoftransport
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C2316486