Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V287334-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $88.90 | |
V287334-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $136.90 | |
V287334-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $307.90 | |
V287334-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $573.90 |
Positive allosteric modulator of mGlu5receptors
Synonyms | Q27089197 | VU1545 | VU-1545 | HY-16951 | N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-5-yl)-4-nitrobenzamide | BDBM50187644 | GTPL4059 | NCGC00370849-01 | DTXSID60469659 | HMS2212K04 | AKOS040745415 | N-[2-(2-fluorophenyl)-5-phenylpyrazol-3-yl]-4-nitrobenza |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (EC50= 9.6 nM, Ki= 156 nM at rat mGlu5). |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 5 receptor |
Product Description | Product Description: |
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IUPAC Name | N-[2-(2-fluorophenyl)-5-phenylpyrazol-3-yl]-4-nitrobenzamide |
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INCHI | InChI=1S/C22H15FN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28) |
InChi Key | BRAZLURTFMCAHU-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4F |
Isomeric SMILES | C1=CC=C(C=C1)C2=NN(C(=C2)NC(=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=CC=C4F |
Alternate CAS | 890764-63-3 |
PubChem CID | 11625520 |
MeSH Entry Terms | 4-nitro-N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-5-yl)benzamide;VU 1545;VU-1545;VU1545 |
Molecular Weight | 402.38 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2115325 | Certificate of Analysis | Aug 22, 2024 | V287334 |
K2115401 | Certificate of Analysis | Aug 22, 2024 | V287334 |
K2115418 | Certificate of Analysis | Aug 22, 2024 | V287334 |
K2115420 | Certificate of Analysis | Aug 22, 2024 | V287334 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 40.24, Max Conc. mM: 100 |
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1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin. (2023) A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation. ANALYTICAL SCIENCES, (1-7). [PMID:37843729] [10.1007/s44211-023-00430-5] |
2. Yao Yuying, Wang Yeru, Zhu Jingru, Guo Zhiqiang, Li Zongqiang, Li Qianru, Liu Su, Wang Yu, Yu Jinghua, Huang Jiadong. (2023) A spatially-controlled DNA triangular prism nanomachine for AND-gated intracellular imaging of ATP in acidic microenvironment. MICROCHIMICA ACTA, 190 (11): (1-9). [PMID:37837554] [10.1007/s00604-023-06010-8] |
3. Xiaomeng Zhou, Saijin Huang, Dan Zhang, Wenfeng Liu, Wenxing Gao, Yumeng Xue, Li Shang. (2023) Gold Nanocluster-Based Fluorescent Microneedle Platform toward Visual Detection of ATP. ANALYTICAL CHEMISTRY, 95 (32): (12104–12112). [PMID:37525420] [10.1021/acs.analchem.3c02242] |
4. Peidong Du, Yanzhe Shen, Baoli Zhang, Shan Li, Minzheng Gao, Ting Wang, Xiaokang Ding, Bingran Yu, Zhen-Gang Wang, Fu-Jian Xu. (2023) A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment. Advanced Science, 10 (9): (2206851). [PMID:36709479] [10.1002/advs.202206851] |
5. Jin Li, Zi-Hui Wang, Ya-Min Dang, Dan-Ni Li, Zhen Liu, Da-Peng Dai, Jian-Ping Cai. (2022) MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. FREE RADICAL BIOLOGY AND MEDICINE, 188 (447). [PMID:35809767] [10.1016/j.freeradbiomed.2022.06.240] |
6. Jie Wei, Yumeng Li, Qingyang Si, Qiao Xiao, Qingmin Chen, Tianhui Jiao, Quansheng Chen, Xiaomei Chen. (2022) Hemin/G-quadruplex based electrochemical sensor for highly sensitive detection of ATP in fish. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 916 (116374). [PMID:] [10.1016/j.jelechem.2022.116374] |
7. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie, Yanyan Yu. (2022) Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS. SENSORS AND ACTUATORS B-CHEMICAL, 363 (131848). [PMID:] [10.1016/j.snb.2022.131848] |
8. Hu Qiongyue, Zhang Tanglei, Yu Hongwei, Ye Lidan. (2022) Selective biosynthesis of retinol in S. cerevisiae. Bioresources and Bioprocessing, 9 (1): (1-14). [PMID:38647788] [10.1186/s40643-022-00512-8] |
9. Xiaoyan He, Jiandi Dong, Huimin Han, Nan Sun, Wenyu Shi, Xiong Lu, Hui Jia, Xiaoquan Lu. (2021) A Novel Electrochemical Aptasensor for the Ultrasensitive Detection of Adenosine Triphosphate Based on DNA-Templated Copolymers. ACS Applied Materials & Interfaces, 13 (30): (35561–35567). [PMID:34296595] [10.1021/acsami.1c10173] |
10. Xianfeng Wang, Xiaolong Chen, Chengxiang Chu, Yuanyi Deng, Mei Yang, Zhong Ji, Faliang Xu, Danqun Huo, Yang Luo, Changjun Hou. (2020) Four-stage signal amplification for trace ATP detection using allosteric probe-conjugated strand displacement and CRISPR/Cpf1 trans-cleavage (ASD-Cpf1). SENSORS AND ACTUATORS B-CHEMICAL, 323 (128653). [PMID:] [10.1016/j.snb.2020.128653] |
11. Wei Wang, Xin Li, Kai Tang, Zhiling Song, Xiliang Luo. (2020) A AuNP-capped cage fluorescent biosensor based on controlled-release and cyclic enzymatic amplification for ultrasensitive detection of ATP. Journal of Materials Chemistry B, 8 (27): (5945-5951). [PMID:32667018] [10.1039/D0TB00666A] |
12. Sun Chao, Zhao Shiyu, Qu Fei, Han Wenli, You Jinmao. (2020) Determination of adenosine triphosphate based on the use of fluorescent terbium(III) organic frameworks and aptamer modified gold nanoparticles. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31814046] [10.1007/s00604-019-4019-z] |
13. Guimei Wang, Xiaoxue Jiang, Nanyan Fu. (2019) Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells. DYES AND PIGMENTS, 171 (107698). [PMID:] [10.1016/j.dyepig.2019.107698] |
14. Liwei Yang, Xiaoqiang Liu, Lele Li, Si Zhang, Hejie Zheng, Yunfei Tang, Huangxian Ju. (2019) A visible light photoelectrochemical sandwich aptasensor for adenosine triphosphate based on MgIn2S4-TiO2 nanoarray heterojunction. BIOSENSORS & BIOELECTRONICS, 142 (111487). [PMID:31276907] [10.1016/j.bios.2019.111487] |
15. Shicai Xu, Chao Zhang, Shouzhen Jiang, Guodong Hu, Xiaoyue Li, Yan Zou, Hanping Liu, Jun Li, Zhenhua Li, Xiaoxin Wang, Mingzhen Li, Jihua Wang. (2019) Graphene foam field-effect transistor for ultra-sensitive label-free detection of ATP. SENSORS AND ACTUATORS B-CHEMICAL, 284 (125). [PMID:] [10.1016/j.snb.2018.12.129] |
16. Qu Fei, Sun Chao, Lv Xiaoxia, You Jinmao. (2018) A terbium-based metal-organic framework@gold nanoparticle system as a fluorometric probe for aptamer based determination of adenosine triphosphate. MICROCHIMICA ACTA, 185 (8): (1-8). [PMID:29978289] [10.1007/s00604-018-2888-1] |
17. Fei Qu, Jingwen Li, Wenli Han, Lian Xia, Jinmao You. (2018) Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction. SENSORS, 18 (7): (2151). [PMID:29973531] [10.3390/s18072151] |
18. Cheng Xia, Cen Yao, Xu Guanhong, Wei Fangdi, Shi Menglan, Xu Xiaoman, Sohail Muhammad, Hu Qin. (2018) Aptamer based fluorometric determination of ATP by exploiting the FRET between carbon dots and graphene oxide. MICROCHIMICA ACTA, 185 (2): (1-8). [PMID:29594479] [10.1007/s00604-018-2683-z] |
19. Fangfang Li, Xuan Hu, Fengyi Wang, Baozhan Zheng, Juan Du, Dan Xiao. (2018) A fluorescent “on-off-on” probe for sensitive detection of ATP based on ATP displacing DNA from nanoceria. TALANTA, 179 (285). [PMID:29310233] [10.1016/j.talanta.2017.09.091] |
20. Yong-Ping Dong, Ying Zhou, Jiao Wang, Jun-Jie Zhu. (2016) Electrogenerated Chemiluminescence Resonance Energy Transfer between Ru(bpy)32+ Electrogenerated Chemiluminescence and Gold Nanoparticles/Graphene Oxide Nanocomposites with Graphene Oxide as Coreactant and Its Sensing Application. ANALYTICAL CHEMISTRY, 88 (10): (5469–5475). [PMID:27101322] [10.1021/acs.analchem.6b00921] |
21. Ying Zhu, Xiao-chun Hu, Shuo Shi, Ru-ru Gao, Hai-liang Huang, Yan-yan Zhu, Xiao-yan Lv, Tian-ming Yao. (2016) Ultrasensitive and universal fluorescent aptasensor for the detection of biomolecules (ATP, adenosine and thrombin) based on DNA/Ag nanoclusters fluorescence light-up system. BIOSENSORS & BIOELECTRONICS, 79 (205). [PMID:26706942] [10.1016/j.bios.2015.12.015] |
22. Qingkun Kong, Meng Li, Chao Ma, Hongmei Yang, Shenguang Ge, Mei Yan, Jinghua Yu. (2015) Ultrasensitive electrochemiluminescence aptasensor based on a graphene/polyaniline composite film modified electrode and CdS quantum dot coated platinum nanostructured networks as labels. RSC Advances, 5 (86): (70345-70351). [PMID:] [10.1039/C5RA12674F] |
23. Weiyan Liu, Hongmei Yang, Shenguang Ge, Lei Shen, Jinghua Yu, Mei Yan, Jiadong Huang. (2015) Application of bimetallic PtPd alloy decorated graphene in peroxydisulfate electrochemiluminescence aptasensor based on Ag dendrites decorated indium tin oxide device. SENSORS AND ACTUATORS B-CHEMICAL, 209 (32). [PMID:] [10.1016/j.snb.2014.11.079] |
24. Meng Li, Hongmei Yang, Chao Ma, Yan Zhang, Shenguang Ge, Jinghua Yu, Mei Yan. (2014) A sensitive signal-off aptasensor for adenosine triphosphate based on the quenching of Ru(bpy)32+-doped silica nanoparticles electrochemiluminescence by ferrocene. SENSORS AND ACTUATORS B-CHEMICAL, 191 (377). [PMID:] [10.1016/j.snb.2013.10.020] |
25. Juanjuan Lu, Mei Yan, Lei Ge, Shenguang Ge, Shaowei Wang, Jixian Yan, Jinghua Yu. (2013) Electrochemiluminescence of blue-luminescent graphene quantum dots and its application in ultrasensitive aptasensor for adenosine triphosphate detection. BIOSENSORS & BIOELECTRONICS, 47 (271). [PMID:23587790] [10.1016/j.bios.2013.03.039] |
1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin. (2023) A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation. ANALYTICAL SCIENCES, (1-7). [PMID:37843729] [10.1007/s44211-023-00430-5] |
2. Yao Yuying, Wang Yeru, Zhu Jingru, Guo Zhiqiang, Li Zongqiang, Li Qianru, Liu Su, Wang Yu, Yu Jinghua, Huang Jiadong. (2023) A spatially-controlled DNA triangular prism nanomachine for AND-gated intracellular imaging of ATP in acidic microenvironment. MICROCHIMICA ACTA, 190 (11): (1-9). [PMID:37837554] [10.1007/s00604-023-06010-8] |
3. Xiaomeng Zhou, Saijin Huang, Dan Zhang, Wenfeng Liu, Wenxing Gao, Yumeng Xue, Li Shang. (2023) Gold Nanocluster-Based Fluorescent Microneedle Platform toward Visual Detection of ATP. ANALYTICAL CHEMISTRY, 95 (32): (12104–12112). [PMID:37525420] [10.1021/acs.analchem.3c02242] |
4. Peidong Du, Yanzhe Shen, Baoli Zhang, Shan Li, Minzheng Gao, Ting Wang, Xiaokang Ding, Bingran Yu, Zhen-Gang Wang, Fu-Jian Xu. (2023) A H2O2-Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment. Advanced Science, 10 (9): (2206851). [PMID:36709479] [10.1002/advs.202206851] |
5. Jin Li, Zi-Hui Wang, Ya-Min Dang, Dan-Ni Li, Zhen Liu, Da-Peng Dai, Jian-Ping Cai. (2022) MTH1 suppression enhances the stemness of MCF7 through upregulation of STAT3. FREE RADICAL BIOLOGY AND MEDICINE, 188 (447). [PMID:35809767] [10.1016/j.freeradbiomed.2022.06.240] |
6. Jie Wei, Yumeng Li, Qingyang Si, Qiao Xiao, Qingmin Chen, Tianhui Jiao, Quansheng Chen, Xiaomei Chen. (2022) Hemin/G-quadruplex based electrochemical sensor for highly sensitive detection of ATP in fish. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 916 (116374). [PMID:] [10.1016/j.jelechem.2022.116374] |
7. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie, Yanyan Yu. (2022) Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS. SENSORS AND ACTUATORS B-CHEMICAL, 363 (131848). [PMID:] [10.1016/j.snb.2022.131848] |
8. Hu Qiongyue, Zhang Tanglei, Yu Hongwei, Ye Lidan. (2022) Selective biosynthesis of retinol in S. cerevisiae. Bioresources and Bioprocessing, 9 (1): (1-14). [PMID:38647788] [10.1186/s40643-022-00512-8] |
9. Xiaoyan He, Jiandi Dong, Huimin Han, Nan Sun, Wenyu Shi, Xiong Lu, Hui Jia, Xiaoquan Lu. (2021) A Novel Electrochemical Aptasensor for the Ultrasensitive Detection of Adenosine Triphosphate Based on DNA-Templated Copolymers. ACS Applied Materials & Interfaces, 13 (30): (35561–35567). [PMID:34296595] [10.1021/acsami.1c10173] |
10. Xianfeng Wang, Xiaolong Chen, Chengxiang Chu, Yuanyi Deng, Mei Yang, Zhong Ji, Faliang Xu, Danqun Huo, Yang Luo, Changjun Hou. (2020) Four-stage signal amplification for trace ATP detection using allosteric probe-conjugated strand displacement and CRISPR/Cpf1 trans-cleavage (ASD-Cpf1). SENSORS AND ACTUATORS B-CHEMICAL, 323 (128653). [PMID:] [10.1016/j.snb.2020.128653] |
11. Wei Wang, Xin Li, Kai Tang, Zhiling Song, Xiliang Luo. (2020) A AuNP-capped cage fluorescent biosensor based on controlled-release and cyclic enzymatic amplification for ultrasensitive detection of ATP. Journal of Materials Chemistry B, 8 (27): (5945-5951). [PMID:32667018] [10.1039/D0TB00666A] |
12. Sun Chao, Zhao Shiyu, Qu Fei, Han Wenli, You Jinmao. (2020) Determination of adenosine triphosphate based on the use of fluorescent terbium(III) organic frameworks and aptamer modified gold nanoparticles. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31814046] [10.1007/s00604-019-4019-z] |
13. Guimei Wang, Xiaoxue Jiang, Nanyan Fu. (2019) Near-infrared squaraine fluorescent probe for imaging adenosine 5′-triphosphate in live cells. DYES AND PIGMENTS, 171 (107698). [PMID:] [10.1016/j.dyepig.2019.107698] |
14. Liwei Yang, Xiaoqiang Liu, Lele Li, Si Zhang, Hejie Zheng, Yunfei Tang, Huangxian Ju. (2019) A visible light photoelectrochemical sandwich aptasensor for adenosine triphosphate based on MgIn2S4-TiO2 nanoarray heterojunction. BIOSENSORS & BIOELECTRONICS, 142 (111487). [PMID:31276907] [10.1016/j.bios.2019.111487] |
15. Shicai Xu, Chao Zhang, Shouzhen Jiang, Guodong Hu, Xiaoyue Li, Yan Zou, Hanping Liu, Jun Li, Zhenhua Li, Xiaoxin Wang, Mingzhen Li, Jihua Wang. (2019) Graphene foam field-effect transistor for ultra-sensitive label-free detection of ATP. SENSORS AND ACTUATORS B-CHEMICAL, 284 (125). [PMID:] [10.1016/j.snb.2018.12.129] |
16. Qu Fei, Sun Chao, Lv Xiaoxia, You Jinmao. (2018) A terbium-based metal-organic framework@gold nanoparticle system as a fluorometric probe for aptamer based determination of adenosine triphosphate. MICROCHIMICA ACTA, 185 (8): (1-8). [PMID:29978289] [10.1007/s00604-018-2888-1] |
17. Fei Qu, Jingwen Li, Wenli Han, Lian Xia, Jinmao You. (2018) Simultaneous Detection of Adenosine Triphosphate and Glucose Based on the Cu-Fenton Reaction. SENSORS, 18 (7): (2151). [PMID:29973531] [10.3390/s18072151] |
18. Cheng Xia, Cen Yao, Xu Guanhong, Wei Fangdi, Shi Menglan, Xu Xiaoman, Sohail Muhammad, Hu Qin. (2018) Aptamer based fluorometric determination of ATP by exploiting the FRET between carbon dots and graphene oxide. MICROCHIMICA ACTA, 185 (2): (1-8). [PMID:29594479] [10.1007/s00604-018-2683-z] |
19. Fangfang Li, Xuan Hu, Fengyi Wang, Baozhan Zheng, Juan Du, Dan Xiao. (2018) A fluorescent “on-off-on” probe for sensitive detection of ATP based on ATP displacing DNA from nanoceria. TALANTA, 179 (285). [PMID:29310233] [10.1016/j.talanta.2017.09.091] |
20. Yong-Ping Dong, Ying Zhou, Jiao Wang, Jun-Jie Zhu. (2016) Electrogenerated Chemiluminescence Resonance Energy Transfer between Ru(bpy)32+ Electrogenerated Chemiluminescence and Gold Nanoparticles/Graphene Oxide Nanocomposites with Graphene Oxide as Coreactant and Its Sensing Application. ANALYTICAL CHEMISTRY, 88 (10): (5469–5475). [PMID:27101322] [10.1021/acs.analchem.6b00921] |
21. Ying Zhu, Xiao-chun Hu, Shuo Shi, Ru-ru Gao, Hai-liang Huang, Yan-yan Zhu, Xiao-yan Lv, Tian-ming Yao. (2016) Ultrasensitive and universal fluorescent aptasensor for the detection of biomolecules (ATP, adenosine and thrombin) based on DNA/Ag nanoclusters fluorescence light-up system. BIOSENSORS & BIOELECTRONICS, 79 (205). [PMID:26706942] [10.1016/j.bios.2015.12.015] |
22. Qingkun Kong, Meng Li, Chao Ma, Hongmei Yang, Shenguang Ge, Mei Yan, Jinghua Yu. (2015) Ultrasensitive electrochemiluminescence aptasensor based on a graphene/polyaniline composite film modified electrode and CdS quantum dot coated platinum nanostructured networks as labels. RSC Advances, 5 (86): (70345-70351). [PMID:] [10.1039/C5RA12674F] |
23. Weiyan Liu, Hongmei Yang, Shenguang Ge, Lei Shen, Jinghua Yu, Mei Yan, Jiadong Huang. (2015) Application of bimetallic PtPd alloy decorated graphene in peroxydisulfate electrochemiluminescence aptasensor based on Ag dendrites decorated indium tin oxide device. SENSORS AND ACTUATORS B-CHEMICAL, 209 (32). [PMID:] [10.1016/j.snb.2014.11.079] |
24. Meng Li, Hongmei Yang, Chao Ma, Yan Zhang, Shenguang Ge, Jinghua Yu, Mei Yan. (2014) A sensitive signal-off aptasensor for adenosine triphosphate based on the quenching of Ru(bpy)32+-doped silica nanoparticles electrochemiluminescence by ferrocene. SENSORS AND ACTUATORS B-CHEMICAL, 191 (377). [PMID:] [10.1016/j.snb.2013.10.020] |
25. Juanjuan Lu, Mei Yan, Lei Ge, Shenguang Ge, Shaowei Wang, Jixian Yan, Jinghua Yu. (2013) Electrochemiluminescence of blue-luminescent graphene quantum dots and its application in ultrasensitive aptasensor for adenosine triphosphate detection. BIOSENSORS & BIOELECTRONICS, 47 (271). [PMID:23587790] [10.1016/j.bios.2013.03.039] |