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VU 6001966 - ≥98%(HPLC), high purity , CAS No.2009052-76-8
Potent and selective negative allosteric modulator of mGlu2receptors
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Potent and selective mGlu2negative allosteric modulator (IC50= 78 nM). Exhibits > 350-fold selectivity for mGlu2over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. CNS penetrant. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4-(4-fluorophenyl)-5-[(1-methylpyrazol-3-yl)methoxy]pyridine-2-carboxamide INCHI InChI=1S/C17H15FN4O2/c1-22-7-6-13(21-22)10-24-16-9-20-15(17(19)23)8-14(16)11-2-4-12(18)5-3-11/h2-9H,10H2,1H3,(H2,19,23) InChi Key SSSNPJKQBYVHBV-UHFFFAOYSA-N Canonical SMILES CN1C=CC(=N1)COC2=CN=C(C=C2C3=CC=C(C=C3)F)C(=O)N Isomeric SMILES CN1C=CC(=N1)COC2=CN=C(C=C2C3=CC=C(C=C3)F)C(=O)N PubChem CID 122539788 Molecular Weight 326.33
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 32.63, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 1.63, Max Conc. mM: 5
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