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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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V275294-50mg | 50mg | In stock | $157.90 | |
V275294-250mg | 250mg | In stock | $711.90 | |
V275294-1g | 1g | In stock | $2,559.90 |
M 1 muscarinic receptor agonist and pan mAChR M 3 , M 5 PAM
Specifications & Purity | Moligand™, ≥99% |
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Biochemical and Physiological Mechanisms | M 1 muscarinic receptor agonist (EC 50 = 3.1 μM) and pan mAChR M 3 , M 5 positive allosteric modulator (PAM). Neuroprotective agent. Active in vitro . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of M 1 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 5 receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at +4°C. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 1-[(4-bromophenyl)methyl]indole-2,3-dione |
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INCHI | InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2 |
InChi Key | DELLOEULSHGYCG-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br |
Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC=C(C=C3)Br |
PubChem CID | 3008304 |
Molecular Weight | 316.15 |
PubChem CID | 3008304 |
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ChEMBL Ligand | CHEMBL523685 |
CAS Registry No. | 79183-37-2 |
GPCRdb Ligand | VU0119498 |
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Solubility | Soluble in DMSO to 100 mM |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P264:Wash hands [and …] thoroughly after handling. P362:Take off contaminated clothing. P337+P313:IF eye irritation persists: Get medical advice/attention. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. |