VU0255035 - ≥98%, high purity , CAS No.1135243-19-4, Antagonist of M 1 receptor;Antagonist of M 2 receptor;Antagonist of M 3 receptor;Antagonist of M 4 receptor;Antagonist of M 5 receptor

Item Number

V275278

• Synonyms: AKOS024457774 | A894354 | N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | VU0255035 hydrate | CS-0027615 | N-{3-oxo-3-[4-(pyridin-4-yl)piperazin-1-yl]propyl}-2,1,3-benzothiadiazole-4-sulfonamide | VU0255035 | BRD-K5
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Highly selective, competitive muscarinic M 1 antagonist (K i = 14.87 nM). 75-fold selectivity over other receptor subtypes for orthosteric site. Blood-brain barrier permeable.
• Storage Temp: Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of M 1 receptor;Antagonist of M 2 receptor;Antagonist of M 3 receptor;Antagonist of M 4 receptor;Antagonist of M 5 receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

VU 0255035 is a highly selective, competitive and brain penetrant muscarinic M1 receptor antagonist with an IC50 of 130 nM. VU 0255035 reduces pilocarpine-induced seizures in mice. VU0255035 is used to examine the role of the M1 receptor in diverse situations