High affinity 5-HT3receptor antagonist (IC50values are 0.04 and 22 nM for human 5HT3Aand 5-HT3ABreceptors respectively). Exhibits partial agonist activity at 5-HT3Areceptors at higher concentrations (EC50= 5.2μM). Also histamine H4receptor antagonist (pKi
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Note
卖完停产，不再备货
Product Description
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.
