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VX-745 - ≥98%, high purity , MAP kinase p38 alpha inhibitor, CAS No.209410-46-8, MAP kinase p38 alpha inhibitor

Moligand™
≥98%

CAS#: 209410-46-8
Formula: C₁₉H₉Cl₂F₂N₃OS
Molecular Weight: 436.27
PubChem CID: 3038525

Item Number

V126681

Grouped product items
SKU	Size	Availability	Price
V126681-10mg	10mg	In stock	$86.90
V126681-25mg	25mg	In stock	$195.90
V126681-50mg	50mg	In stock	$260.90
V126681-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$469.90
V126681-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,057.90

Potent, selective p38 alpha MAPK inhibitor

View related series

mitogen-activated protein kinase 11 Inhibitor mitogen-activated protein kinase 14 Inhibitor

Basic Description

Synonyms	209410-46-8\|VX-745\|Neflamapimod\|5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one\|VX 745\|VX745\|5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one\|C19H9Cl2F2N3OS\|VRT-031745\|Neflamapimod [
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	VX-745 is highly potent and selective p38α inhibitor (IC50 = 10 nM). VX-745 also blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 177 nM). VX-745 displays 1000-fold selectivity over closely related kinases, including ERK1, MK2 and
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	MAP kinase p38 alpha inhibitor
Note	Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Names and Identifiers

IUPAC Name	5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one
INCHI	InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H
InChi Key	VEPKQEUBKLEPRA-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
Isomeric SMILES	C1=CC(=C(C(=C1)Cl)C2=C3C=CC(=NN3C=NC2=O)SC4=C(C=C(C=C4)F)F)Cl
PubChem CID	3038525
Molecular Weight	436.27

CAS Registry No.

DiscoveRx TREEspot

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
L2123153	Certificate of Analysis	Oct 08, 2023	V126681
L2123154	Certificate of Analysis	Oct 08, 2023	V126681
L2123399	Certificate of Analysis	Oct 08, 2023	V126681
L2123421	Certificate of Analysis	Oct 08, 2023	V126681
L2123430	Certificate of Analysis	Oct 08, 2023	V126681

Solubility

DMSO ≥60mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL；Chloroform, DMSO, Methanol

Sensitivity

light sensitive

Melt Point(°C)

259-262°C (dec.)

References

1. Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, O'Keefe SJ, Scapin G. (2003) Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity.. Nat Struct Biol, 10 (9): (764-9). [PMID:12897767]
2. Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT et al.. (2008) A quantitative analysis of kinase inhibitor selectivity.. Nat Biotechnol, 26 (1): (127-32). [PMID:18183025]
3. Munoz L, Ralay Ranaivo H, Roy SM, Hu W, Craft JM, McNamara LK, Chico LW, Van Eldik LJ, Watterson DM. (2007) A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.. J Neuroinflammation, 4 (3): (21). [PMID:17784957]
4. Duffy JP, Harrington EM, Salituro FG, Cochran JE, Green J, Gao H, Bemis GW, Evindar G, Galullo VP, Ford PJ et al.. (2011) The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.. ACS Med Chem Lett, 2 (10): (758-63). [PMID:24900264]
5. Alam JJ. (2015) Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats.. J Alzheimers Dis, 48 (1): (219-27). [PMID:26401942]
6. Alam J, Blackburn K, Patrick D. (2017) Neflamapimod: Clinical Phase 2b-Ready Oral Small Molecule Inhibitor of p38α to Reverse Synaptic Dysfunction in Early Alzheimer's Disease.. J Prev Alzheimers Dis, 4 (4): (273-278). [PMID:29181493]

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VX-745 - ≥98%, high purity , MAP kinase p38 alpha inhibitor, CAS No.209410-46-8, MAP kinase p38 alpha inhibitor

Basic Description

Product Properties

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

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References

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