Your company account is blocked and you cannot place orders. If you have questions, please contact your company administrator.

W 54011 - 97%, high purity , CAS No.405098-33-1, Antagonist of C5a 1 receptor

Item Number
W287176
Grouped product items
SKUSizeAvailabilityPrice Qty
W287176-1mg
1mg
In stock
$94.90
W287176-5mg
5mg
In stock
$189.90
W287176-10mg
10mg
In stock
$284.90
W287176-25mg
25mg
In stock
$641.90
W287176-50mg
50mg
In stock
$890.90
W287176-100mg
100mg
In stock
$1,603.90

High affinity C5a receptor antagonist

Basic Description

SynonymsN-(4-(Dimethylamino)benzyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride, AldrichCPR | n-((4-(dimethylamino)phenyl)methyl)-1,2,3,4-tetrahydro-7-methoxy-n-(4-(1-methylethyl)phenyl)-1-naphthalenecarboxamide hcl |
Specifications & PurityMoligand™, ≥97%
Biochemical and Physiological MechanismsHigh affinity C5a receptor antagonist (Ki= 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+mobilization in human neutrophils (IC50values are 1.6, 2.7 and 3.1 nM, respectively).
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of C5a 1 receptor

Associated Targets(Human)

C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CSNK1D Tchem Casein kinase I delta (4546 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U2OS (164939 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BRPF1 Tchem Peregrin (2217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK-293T (167025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Aplnr Apelin receptor (201 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences
Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

DailyMed: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

DailyMed: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

Expert: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

Expert: [1]


FDA: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

DailyMed: [1]


Wikipedia: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

Other: [1] , [2]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

ClinicalTrials: [1]


PubMed: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

PubMed: [1] , [2]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

DOI: [1]


Other: [1]


PubMed: [1]


Tyrosine-protein kinase ABL inhibitorINHIBITORALA1862Tyrosine-protein kinase ABLSINGLE PROTEINHomo sapiens

PubMed: [1]


Names and Identifiers

IUPAC Name N-[[4-(dimethylamino)phenyl]methyl]-7-methoxy-N-(4-propan-2-ylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide;hydrochloride
INCHI InChI=1S/C30H36N2O2.ClH/c1-21(2)23-11-16-26(17-12-23)32(20-22-9-14-25(15-10-22)31(3)4)30(33)28-8-6-7-24-13-18-27(34-5)19-29(24)28;/h9-19,21,28H,6-8,20H2,1-5H3;1H
InChi Key UKBJWRMNGCDKNL-UHFFFAOYSA-N
Canonical SMILES CC(C)C1=CC=C(C=C1)N(CC2=CC=C(C=C2)N(C)C)C(=O)C3CCCC4=C3C=C(C=C4)OC.Cl
Isomeric SMILES CC(C)C1=CC=C(C=C1)N(CC2=CC=C(C=C2)N(C)C)C(=O)C3CCCC4=C3C=C(C=C4)OC.Cl
PubChem CID 5311121
Molecular Weight 493.08

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
C2304118Certificate of AnalysisOct 25, 2022 W287176
C2304119Certificate of AnalysisOct 25, 2022 W287176
C2304120Certificate of AnalysisOct 25, 2022 W287176
C2304121Certificate of AnalysisOct 25, 2022 W287176
C2304122Certificate of AnalysisOct 25, 2022 W287176
C2304123Certificate of AnalysisOct 25, 2022 W287176

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 24.65, Max Conc. mM: 50
Sensitivitylight & Moisture sensitive

Related Documents

Solution Calculators