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W 54011 - 97%, high purity , CAS No.405098-33-1, Antagonist of C5a 1 receptor
High affinity C5a receptor antagonist
Basic Description Synonyms N-(4-(Dimethylamino)benzyl)-N-(4-isopropylphenyl)-7-methoxy-1,2,3,4-tetrahydronaphthalene-1-carboxamide hydrochloride, AldrichCPR | n-((4-(dimethylamino)phenyl)methyl)-1,2,3,4-tetrahydro-7-methoxy-n-(4-(1-methylethyl)phenyl)-1-naphthalenecarboxamide hcl | Specifications & Purity Moligand™, ≥97% Biochemical and Physiological Mechanisms High affinity C5a receptor antagonist (Ki= 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+mobilization in human neutrophils (IC50values are 1.6, 2.7 and 3.1 nM, respectively). Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of C5a 1 receptor
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens Tyrosine-protein kinase ABL inhibitor INHIBITOR ALA1862 Tyrosine-protein kinase ABL SINGLE PROTEIN Homo sapiens
Names and Identifiers IUPAC Name N-[[4-(dimethylamino)phenyl]methyl]-7-methoxy-N-(4-propan-2-ylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide;hydrochloride INCHI InChI=1S/C30H36N2O2.ClH/c1-21(2)23-11-16-26(17-12-23)32(20-22-9-14-25(15-10-22)31(3)4)30(33)28-8-6-7-24-13-18-27(34-5)19-29(24)28;/h9-19,21,28H,6-8,20H2,1-5H3;1H InChi Key UKBJWRMNGCDKNL-UHFFFAOYSA-N Canonical SMILES CC(C)C1=CC=C(C=C1)N(CC2=CC=C(C=C2)N(C)C)C(=O)C3CCCC4=C3C=C(C=C4)OC.Cl Isomeric SMILES CC(C)C1=CC=C(C=C1)N(CC2=CC=C(C=C2)N(C)C)C(=O)C3CCCC4=C3C=C(C=C4)OC.Cl PubChem CID 5311121 Molecular Weight 493.08
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 24.65, Max Conc. mM: 50 Sensitivity light & Moisture sensitive
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