W146 - ≥98%(HPLC), high purity , CAS No.909725-61-7, Antagonist of S1P 1 receptor

Item Number
W287979
Grouped product items
SKUSizeAvailabilityPrice Qty
W287979-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$139.90
W287979-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$469.90
W287979-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$749.90
W287979-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,499.90

Potent and selective S1P1receptor antagonist

View related series
S1P1 receptor Antagonist

Basic Description

SynonymsML056 | W 146 | ML5 | HY-101395 | {(3r)-3-Amino-4-[(3-Hexylphenyl)amino]-4-Oxobutyl}phosphonic Acid | DTXSID50425901 | BDBM50324676 | [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid | GTPL2931 | ML056 | (R)-(3-Amino-4-((3-hexylphenyl)amino)-4-
Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent sphingosine-1-phosphate receptor S1P1selective antagonist (Ki= 18 nM); displays no effect at S1P2, S1P3or S1P5. Enhances capillary leakage and restores lymphocyte egressin vivo.Potent S1P(1) competitive antagonist; Ki = 10-77 nM.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of S1P 1 receptor
Product Description

Product description:

W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice.


Application:

W146 hydrate has been used to assess vascular permeability in mice.

Associated Targets(Human)

S1PR1 Tclin Sphingosine 1-phosphate receptor 1 (4 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR4 Tclin Sphingosine 1-phosphate receptor Edg-6 (1041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR3 Tclin Sphingosine 1-phosphate receptor Edg-3 (2543 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR2 Tchem Sphingosine 1-phosphate receptor Edg-5 (1593 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
S1PR5 Tclin Sphingosine 1-phosphate receptor Edg-8 (813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid
INCHI InChI=1S/C16H27N2O4P/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22)/t15-/m1/s1
InChi Key FWJRVGZWNDOOFH-OAHLLOKOSA-N
Canonical SMILES CCCCCCC1=CC(=CC=C1)NC(=O)C(CCP(=O)(O)O)N
Isomeric SMILES CCCCCCC1=CC(=CC=C1)NC(=O)[C@@H](CCP(=O)(O)O)N
PubChem CID 6857802
Molecular Weight 342.37

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
I2413556Certificate of AnalysisJun 28, 2024 W287979
I2413557Certificate of AnalysisJun 28, 2024 W287979
I2413558Certificate of AnalysisJun 28, 2024 W287979
I2413559Certificate of AnalysisJun 28, 2024 W287979
I2413561Certificate of AnalysisJun 28, 2024 W287979
I2413564Certificate of AnalysisJun 28, 2024 W287979
I2413565Certificate of AnalysisJun 28, 2024 W287979
I2413580Certificate of AnalysisJun 28, 2024 W287979

Chemical and Physical Properties

SolubilitySolvent:3eq. NaOH, Max Conc. mg/mL: 6.85, Max Conc. mM: 20

Related Documents

Solution Calculators