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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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W287979-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $139.90 | |
W287979-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $469.90 | |
W287979-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $749.90 | |
W287979-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,499.90 |
Potent and selective S1P1receptor antagonist
Synonyms | ML056 | W 146 | ML5 | HY-101395 | {(3r)-3-Amino-4-[(3-Hexylphenyl)amino]-4-Oxobutyl}phosphonic Acid | DTXSID50425901 | BDBM50324676 | [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid | GTPL2931 | ML056 | (R)-(3-Amino-4-((3-hexylphenyl)amino)-4- |
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Specifications & Purity | Moligand™, ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | Potent sphingosine-1-phosphate receptor S1P1selective antagonist (Ki= 18 nM); displays no effect at S1P2, S1P3or S1P5. Enhances capillary leakage and restores lymphocyte egressin vivo.Potent S1P(1) competitive antagonist; Ki = 10-77 nM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of S1P 1 receptor |
Product Description | Product description: W146 hydrate functions as an orthosteric antagonist. It is associated with blood lymphopenia and lung edema in mice. Application: W146 hydrate has been used to assess vascular permeability in mice. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(3R)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid |
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INCHI | InChI=1S/C16H27N2O4P/c1-2-3-4-5-7-13-8-6-9-14(12-13)18-16(19)15(17)10-11-23(20,21)22/h6,8-9,12,15H,2-5,7,10-11,17H2,1H3,(H,18,19)(H2,20,21,22)/t15-/m1/s1 |
InChi Key | FWJRVGZWNDOOFH-OAHLLOKOSA-N |
Canonical SMILES | CCCCCCC1=CC(=CC=C1)NC(=O)C(CCP(=O)(O)O)N |
Isomeric SMILES | CCCCCCC1=CC(=CC=C1)NC(=O)[C@@H](CCP(=O)(O)O)N |
PubChem CID | 6857802 |
Molecular Weight | 342.37 |
PubChem CID | 6857802 |
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BindingDB Ligand | 50324676 |
CAS Registry No. | 909725-61-7 |
ChEMBL Ligand | CHEMBL1221649 |
RCSB PDB Ligand | ML5 |
GPCRdb Ligand | W146 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2413556 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413557 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413558 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413559 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413561 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413564 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413565 | Certificate of Analysis | Jun 28, 2024 | W287979 |
I2413580 | Certificate of Analysis | Jun 28, 2024 | W287979 |
Solubility | Solvent:3eq. NaOH, Max Conc. mg/mL: 6.85, Max Conc. mM: 20 |
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