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WAY 208466 dihydrochloride - 98%, high purity , CAS No.633304-27-5, Agonist of 5-HT 6 receptor

Moligand™
≥98%

CAS#: 633304-27-5
Formula: C₁₇H₁₈FN₃O₂S・2HCl
Molecular Weight: 420.33
PubChem CID: 10337743

Item Number

W332774

Grouped product items
SKU	Size	Availability	Price	Qty
W332774-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$127.90

a high affinity, selective SR-6 (5-HT6) agonist

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5-HT6 receptor Agonist

Basic Description

Synonyms	WAY-208466\|633304-27-5\|3-((3-Fluorophenyl)sulfonyl)-N,N-dimethyl-1H-pyrrolo(2,3-b)pyridine-1-ethanamine\|0AXW9ALG9W\|CHEMBL571858\|2-[3-(3-fluorophenyl)sulfonylpyrrolo[2,3-b]pyridin-1-yl]-N,N-dimethylethanamine\|WAY-208,466\|1H-Pyrrolo(2,3-b)pyridine-1-ethanam
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of 5-HT 6 receptor
Product Description	WAY 208466 dihydrochloride is a high affinity, selective SR-6 (5-HT6) receptor agonist with an EC\|50\|of 7.3 nM at the human SR-6 (5-HT6) receptor. This compound has been shown to elevate cortical GABA levels in rat frontal cortex. WAY 208466 dihydrochloride is an activator of Serotonin.

Associated Targets

DRD2 Tclin D(2) dopamine receptor 0 Activities

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DRD4 Tchem D(4) dopamine receptor 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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DRD3 Tclin D(3) dopamine receptor 0 Activities

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HTR1B Tclin 5-hydroxytryptamine receptor 1B 0 Activities

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HTR2A Tclin 5-hydroxytryptamine receptor 2A 0 Activities

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HTR7 Tclin 5-hydroxytryptamine receptor 7 0 Activities

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HTR1D Tclin 5-hydroxytryptamine receptor 1D 0 Activities

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HTR1F Tclin 5-hydroxytryptamine receptor 1F 0 Activities

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HTR2C Tclin 5-hydroxytryptamine receptor 2C 0 Activities

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HTR6 Tchem 5-hydroxytryptamine receptor 6 7 Activities

Discover Target: HTR6

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Names and Identifiers

IUPAC Name	2-[3-(3-fluorophenyl)sulfonylpyrrolo[2,3-b]pyridin-1-yl]-N,N-dimethylethanamine
INCHI	InChI=1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3
InChi Key	SFSFIDVAEMDPIP-UHFFFAOYSA-N
Canonical SMILES	CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F
Isomeric SMILES	CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F
Alternate CAS	633304-27-5
PubChem CID	10337743
MeSH Entry Terms	N-(2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo(2,3-b)pyridin-1-yl)ethyl)-N,N-dimethylamine;WAY-208466
Molecular Weight	420.33

Solubility

Soluble in DMSO (80 mM), and water (80 mM).

Refractive Index

n20D~1.61 (Predicted)

Melt Point(°C)

184.2-189.6° C

References

1. Schechter LE, Lin Q, Smith DL, Zhang G, Shan Q, Platt B, Brandt MR, Dawson LA, Cole D, Bernotas R et al.. (2008) Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466.. Neuropsychopharmacology, 33 (6): (1323-35). [PMID:17625499]
2. Bernotas RC, Lenicek S, Antane S, Cole DC, Harrison BL, Robichaud AJ, Zhang GM, Smith D, Platt B, Lin Q et al.. (2009) Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.. Bioorg Med Chem, 17 (14): (5153-63). [PMID:19523834]

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