Wedelolactone - 10mM in DMSO, high purity , CAS No.524-12-9

Item Number

W424498

• Synonyms: Wedelolactone | 524-12-9 | 7-Methoxy-5,11,12-trihydroxycoumestan | 7-Methoxy-5,11,12-trihydroxy-coumestan | IKK Inhibitor II | 1,8,9-Trihydroxy-3-methoxycoumestan | CHEMBL97453 | 0K6L725GNS | CHEBI:10037 | 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one | 5,11,12
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.Selective
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

Wedelolactone, a compound originally extracted from Eclipta alba, has been shown to inhibit caspase-11, which is a key regulator of proinflammatory cytokine IL-1β maturation and pathological apoptosis. Mechanistic studies suggest that caspase-11 is inhibited by reduction of NF-κB-mediated transcription. Furthermore, this compound has been shown to inhibit IKKγ, a kinase that is crucial for activation of NF-κB, as well as IKK α and IKK β. Weldelolactone also displays potent trypsin inhibition capacities. Additional studies suggest that Wedelolactone contains antagonistic properties towards two PLA2 myotoxins that were isolated from Agkistrodon contortix laticinctus and Crotalus virdis virdis. This agent has also been noted to contain antihepatotoxic behavior consequentially protecting primary cultured liver cells from the toxicity of CC14, Phalloidin, and galactosamine, and inhibit 5-lipoxygenase (5-LO)) activity in porcine leukocytes.
Inhibits caspase-11; a key regulator of proinflammatory cytokine IL-1β maturation and apoptosis.