WH-4-023 - ≥98%(HPLC), high purity , CAS No.837422-57-8, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase
WH-4-023 - ≥98%(HPLC), high purity , CAS No.837422-57-8, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase
WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of SRC proto-oncogene; non-receptor tyrosine kinase
1.Martin MW, Newcomb J, Nunes JJ, McGowan DC, Armistead DM, Boucher C, Buchanan JL, Buckner W, Chai L, Elbaum D et al.. (2006) Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.. J Med Chem, 49 (16):(4981-91). [PMID:16884310][10.1021/op500134e]
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B2215794