WM-8014 - 10mM in DMSO, high purity , CAS No.2055397-18-5

Item Number

W422493

Grouped product items
SKU	Size	Availability	Price	Qty
W422493-1ml	1ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$278.90

Histone Acetyltransferase Inhibitors

Basic Description

Specifications & Purity	10mM in DMSO
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information WM-8014 WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM. Targets KAT6A (Cell-free assay) 8 nM In vitro WM-8014 induces cell cycle arrest in embryonic day (E)14.5 mouse embryonic fibroblasts.Cells treated with WM-8014 failed to proliferate after ten days of treatment (IC50 2.4 μM). Higher doses of WM-8014 (up to 40 μM) did not accelerate growth arrest, which after eight days of treatment was irreversible. In vivo WM-8014 potentiates oncogene-induced senescence in a zebrafish model of hepatocellular carcinoma.

Associated Targets(Human)

KAT6B Tchem Histone acetyltransferase KAT6B (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT6A Tchem Histone acetyltransferase KAT6A (4 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KAT6A Tchem Histone acetyltransferase KAT6A (320 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KAT6B Tchem Histone acetyltransferase KAT6B (12 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N'-(benzenesulfonyl)-2-fluoro-3-methyl-5-phenylbenzohydrazide
INCHI	InChI=1S/C20H17FN2O3S/c1-14-12-16(15-8-4-2-5-9-15)13-18(19(14)21)20(24)22-23-27(25,26)17-10-6-3-7-11-17/h2-13,23H,1H3,(H,22,24)
InChi Key	PHHZKBMVRPULAW-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES	CC1=CC(=CC(=C1F)C(=O)NNS(=O)(=O)C2=CC=CC=C2)C3=CC=CC=C3
PubChem CID	133053564
Molecular Weight	384.42

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Basic Description