WYE-354 - ≥98%, high purity , CAS No.1062169-56-5, Inhibitor of mechanistic target of rapamycin kinase

Item Number

W128007

• Synonyms: WYE-354|1062169-56-5|methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate|WYE354|WYE 354|methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: WYE-354 is an inhibitor of several PI3Ks at micromolar levels. WYE-354 is an effective inhibitor of both mTORC1 and mTORC2 in HEK293 cells. WYE-354 significantly blocks mTOR signaling and Akt activation in U87MG and MDA361 cells. WYE-354 is a potent inhib
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of mechanistic target of rapamycin kinase
• Note: 卖完停产，不再备货

Product Description

WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
A potent, specific, and ATP-competitive inhibitor to mTOR with IC50 of 5 nM