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XAP 044 - ≥98%(HPLC), high purity , CAS No.196928-50-4, Allosteric modulator of mGlu 7 receptor

Item Number
X288039
Grouped product items
SKUSizeAvailabilityPrice Qty
X288039-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
X288039-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$176.90
X288039-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$369.90
X288039-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$559.90
X288039-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$839.90

Potent and selective mGlu7antagonist

Basic Description

Specifications & PurityMoligand™, ≥98%(HPLC)
Biochemical and Physiological MechanismsPotent and selective mGlu7antagonist (IC50= 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7deficient mice. Exhibits novel activity by binding to the mGlu7Venus fly
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 7 receptor
Product Description

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.

Associated Targets(Human)

GRM7 Tchem Metabotropic glutamate receptor 7 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 7-hydroxy-3-(4-iodophenoxy)chromen-4-one
INCHI InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
InChi Key XXZKJJYWINSUMJ-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
Isomeric SMILES C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
PubChem CID 5428913
MeSH Entry Terms 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;XAP044 compound
Molecular Weight 380.13

Certificates

C of A & Other Certificates

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 38.01, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.6, Max Conc. mM: 20
Sensitivitylight sensitive

Safety and Hazards(GHS)

RIDADR NONHforallmodesoftransport

Related Documents

References

1. Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S et al..  (2014)  Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior..  J Biol Chem,  289  (16): (10975-87).  [PMID:24596089] [10.1021/op500134e]

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