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SKU | Size | Availability | Price | Qty |
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X288039-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $109.90 | |
X288039-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $176.90 | |
X288039-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $369.90 | |
X288039-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $559.90 | |
X288039-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $839.90 |
Potent and selective mGlu7antagonist
Specifications & Purity | Moligand™, ≥98%(HPLC) |
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Biochemical and Physiological Mechanisms | Potent and selective mGlu7antagonist (IC50= 88 nM); inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice. Displays no effects on the LTP of mGlu7deficient mice. Exhibits novel activity by binding to the mGlu7Venus fly |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 7 receptor |
Product Description |
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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IUPAC Name | 7-hydroxy-3-(4-iodophenoxy)chromen-4-one |
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INCHI | InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H |
InChi Key | XXZKJJYWINSUMJ-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I |
Isomeric SMILES | C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I |
PubChem CID | 5428913 |
MeSH Entry Terms | 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one;XAP044 compound |
Molecular Weight | 380.13 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.01, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 7.6, Max Conc. mM: 20 |
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Sensitivity | light sensitive |
RIDADR | NONHforallmodesoftransport |
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1. Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S et al.. (2014) Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior.. J Biol Chem, 289 (16): (10975-87). [PMID:24596089] [10.1021/op500134e] |