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XAV-939 - ≥98%, high purity , CAS No.284028-89-3

≥98%

CAS#: 284028-89-3
Formula: C₁₄H₁₁F₃N₂OS
Molecular Weight: 312.31
MDL number: MFCD16879017
PubChem CID: 135418940

Item Number

X125899

Grouped product items
SKU	Size	Availability	Price
X125899-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
X125899-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$70.90
X125899-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$159.90
X125899-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$331.90
X125899-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$747.90

Discover XAV-939 by Aladdin Scientific in ≥98% for only $58.90. Available - in Ligands at Aladdin Scientific. Potent tankyrase inhibitor. Inhibitor of Wnt/β-catenin signaling. Tags: Pyrimidines, Six-Membered Heterocyclic Compounds.

View related series

Pyrimidines Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	284028-89-3\|XAV-939\|XAV939\|3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one\|XAV 939\|2-[4-(trifluoromethyl)phenyl]-1,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one\|CHEBI:62878\|CHEMBL1086580\|XAV-939 (GMP)\|CID 2726824\|2-
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Product Description	XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM, regulates axin levels and does not affect CRE, NF-κB or TGF-β. A potent inhibitor of beta-catenin, TNKS1, and TNKS2.

Associated Targets

TNKS Tchem Tankyrase-1 20 Activities

Discover Target: TNKS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP3 Tclin Poly [ADP-ribose] polymerase 3 2 Activities

Discover Target: PARP3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP1 Tclin Poly [ADP-ribose] polymerase 1 8 Activities

Discover Target: PARP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PARP2 Tclin Poly [ADP-ribose] polymerase 2 9 Activities

Discover Target: PARP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AXIN2 Tchem Axin-2 1 Activities

Discover Target: AXIN2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WNT3A Tchem Protein Wnt-3a 1 Activities

Discover Target: WNT3A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNKS2 Tchem Tankyrase-2 21 Activities

Discover Target: TNKS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[4-(trifluoromethyl)phenyl]-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
INCHI	InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChi Key	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Canonical SMILES	C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F
Isomeric SMILES	C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F
WGK Germany	3
PubChem CID	135418940
Molecular Weight	312.31

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
L1828016	Certificate of Analysis	Jun 19, 2024	X125899
L2301172	Certificate of Analysis	Dec 07, 2023	X125899
L2301171	Certificate of Analysis	Dec 07, 2023	X125899
A2206323	Certificate of Analysis	Oct 24, 2023	X125899
L1828017	Certificate of Analysis	Oct 18, 2022	X125899

Solubility

Soluble in 1:5 EtOH:PBS (pH 7.2) (~0.15 mg/ml), DMSO (~2 mg/ml), DMF (~5 mg/ml), water (<1 mg/ml) at 25 °C, and ethanol (<1 mg/ml) at 25 °C.

Sensitivity

Heat Sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H301:Toxic if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	3

References

1. Fagnocchi L et al.. (2016) A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.. Nat Commun, 7 (11903). [PMID:27301576]
2. Polley A et al.. (2020) Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro.. Int J Cell Biol, 2020 (2045969). [PMID:32328102]
3. Du B et al.. (2020) Long non-coding RNA MALAT1 suppresses the proliferation and migration of endothelial progenitor cells in deep vein thrombosis by regulating the Wnt/ß-catenin pathway.. Exp Ther Med, 20 (4): (3138-3146). [PMID:32855682]
4. Hamidi S et al.. (2020) Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation.. Development, 147 (3): [PMID:32014865]
5. Lafon-Hughes L et al.. (2014) VERO cells harbor a poly-ADP-ribose belt partnering their epithelial adhesion belt.. PeerJ, 2 (e617). [PMID:25332845]

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