Selective ERRαinverse agonist (IC50= ~400 nM). Displays no antagonist activity at ERRγor ERαat concentrations below 10μM. Interferes with PPARγcoactivator-1α(PGC-1α)/ERRα-dependent signaling: inhibits PGC-1αinduction of ERRαand MAO-B gene expression and d
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of Estrogen-related receptor-α
Product Description
application：
XCT790 has been used:
as an estrogen-related receptor (ERR)α inverse agonist in C2C12 myotubes
as an estrogen-related receptor (ERR)α inverse agonist to elucidate decidualization functionality of ERRα in endometrial embryonic stem cells
as an autophagy inducer in human neuroblastoma SH-SY5Y and HeLa cell lines
1.Lanvin O, Bianco S, Kersual N, Chalbos D, Vanacker JM. (2007) Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.. J Biol Chem, 282 (39):(28328-34). [PMID:17631492][10.1021/op500134e]
2.Kong X, Fan H, Liu X, Wang R, Liang J, Gupta N, Chen Y, Fang F, Chang Y. (2009) Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.. Mol Pharmacol, 76 (4):(854-60). [PMID:19602572][10.1021/op500134e]
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