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XEN445 - 98% (HPLC), high purity , CAS No.1515856-92-4

≥98%(HPLC)

CAS#: 1515856-92-4
Formula: C₁₈H₁₇F₃N₂O₃
Molecular Weight: 366.33
PubChem CID: 72736173

Item Number

X167460

Grouped product items
SKU	Size	Availability	Price
X167460-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$90.90
X167460-10mg	10mg	In stock	$139.90
X167460-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$314.90
X167460-50mg	50mg	In stock	$585.90
X167460-100mg	100mg	In stock	$1,053.90

Selective endothelial lipase inhibitor

Basic Description

Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective endothelial lipase (EL) inhibitor (IC50= 237 nM for human EL). Exhibits >20-fold selectivity for EL over lipoprotein lipase (LPL) and hepatic lipase (HL). Increases high density lipoprotein cholesterol (HDLc) plasma levels in mice. Orally bioava
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

LIPG Tchem Endothelial lipase (3 Activities)

Discover Target: LIPG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LPL Tchem Lipoprotein lipase (101 Activities)

Discover Target: LPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LIPC Tchem Hepatic lipase (436 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LIPG Tchem Endothelial lipase (1021 Activities)

Discover Target: LIPG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
INCHI	InChI=1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
InChi Key	NBGRERFNOKZQLO-AWEZNQCLSA-N
Canonical SMILES	C1CN(CC1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
Isomeric SMILES	C1CN(C[C@H]1OCC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)C(=O)O
PubChem CID	72736173
Molecular Weight	366.33

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
J2120304	Certificate of Analysis	Aug 09, 2024	X167460
J2120305	Certificate of Analysis	Aug 09, 2024	X167460
J2120306	Certificate of Analysis	Aug 09, 2024	X167460
J2120308	Certificate of Analysis	Aug 09, 2024	X167460
J2120309	Certificate of Analysis	Aug 09, 2024	X167460

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