Potent, selective, reversible IP 3 receptor antagonist (IC 50 = 350 nM). Inhibits IP 3 -mediated Ca 2+ release from ER and SR. 30-Fold selectivity over ryanodine receptor. Inhibits voltage-dependent Ca 2+ and K + channels at higher concentrations.
Storage Temp
Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of IP 3R1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.
Associated Targets(Human)
ITPR1TchemInositol 1,4,5-trisphosphate receptor type 1 (0 Activities)
1.Gupta K et al.. (2020) Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel.. Biomaterials, 259 (120283). [PMID:32827796]
2.Shen Y et al.. (2019) Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions.. Nat Commun, 10 (2924). [PMID:31266950]
3.Malek M et al.. (2022) Inositol triphosphate-triggered calcium release from the endoplasmic reticulum induces lysosome biogenesis via TFEB/TFE3.. J Biol Chem, 298 (3):(101740). [PMID:35182526]
4.Dulloo I et al.. (2022) iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2.. Nat Commun, 13 (1257). [PMID:35273168]
5.Luo R et al.. (2019) Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.. FEBS J, 286 (21):(4356-4373). [PMID:31230413]
6.Fazal L et al.. (2017) Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.. Circ Res, 120 (4):(645-657). [PMID:28096195]
7.James TD et al.. (2019) Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling.. Elife, 8 [PMID:31180325]
8.Wang J et al.. (2020) Melatonin fine-tunes intracellular calcium signals and eliminates myocardial damage through the IP3R/MCU pathways in cardiorenal syndrome type 3.. Biochem Pharmacol, 174 (113832). [PMID:32006470]
9.Pick JE et al.. (2017) mGluR long-term depression regulates GluA2 association with COPII vesicles and exit from the endoplasmic reticulum.. EMBO J, 36 (2):(232-244). [PMID:27856517]
10.Chen T et al.. (2019) ROS-Mediated Mitochondrial Dysfunction and ER Stress Contribute to Compression-Induced Neuronal Injury.. Neuroscience, 416 (268-280). [PMID:31425734]
11.Jiang C et al.. (2019) VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine.. Neuropsychopharmacology, 44 (5):(971-981). [PMID:30504797]
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