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XL019 - 98% , high purity , CAS No.945755-56-6, Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3 Specifications & Purity: 98%
Basic Description Synonyms XL019|945755-56-6|(S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide|XL-019|4L1AM42NVA|(2S)-N-[4-[2-[[4-(4-Morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide|(2S)-N-[4-(2-{[4-(MORPHOLIN-4-YL)PHENYL Specifications & Purity 98% Storage Temp Store at -20°C Shipped In Dry ice Action Type INHIBITOR Mechanism of action Inhibitor of Janus kinase 1;Inhibitor of Janus kinase 2;Inhibitor of Janus kinase 3
Names and Identifiers IUPAC Name (2S)-N-[4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide INCHI InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1 InChi Key ISOCDPQFIXDIMS-QHCPKHFHSA-N Canonical SMILES C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5 Isomeric SMILES C1C[C@H](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5 PubChem CID 57990869 Molecular Weight 444.53
Chemical and Physical Properties Solubility DMSO 16 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
References 1. Forsyth T, Kearney PC, Kim BG, Johnson HW, Aay N, Arcalas A, Brown DS, Chan V, Chen J, Du H et al. . (2012) SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.. Bioorg Med Chem Lett, 22 (24): (7653-8). [PMID:23127890 ]
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G2221406