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XMD-12 , CAS No.X614900, Inhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of leucine rich repeat kinase 2

Item Number
X614900
Grouped product items
SKUSizeAvailabilityPrice Qty
X614900-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$220.90
X614900-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$990.90
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View related series
aurora kinase A Inhibitor aurora kinase B Inhibitor leucine rich repeat kinase 2 Inhibitor

Basic Description

Synonymscompound 1;XMD12
Specifications & PurityMoligand™
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of aurora kinase A;Inhibitor of aurora kinase B;Inhibitor of leucine rich repeat kinase 2

Associated Targets(Human)

LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AURKA Tchem Aurora kinase A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
AURKB Tchem Aurora kinase B (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MAPK7 Tchem Mitogen-activated protein kinase 7 (929 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DCLK1 Tchem Serine/threonine-protein kinase DCLK1 (1025 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LRRK2 Tchem Leucine-rich repeat serine/threonine-protein kinase 2 (6390 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-[4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
INCHI InChI=1S/C24H26N6O2/c1-28-20-6-4-3-5-19(20)23(32)29(2)21-15-25-24(27-22(21)28)26-16-7-9-17(10-8-16)30-13-11-18(31)12-14-30/h3-10,15,18,31H,11-14H2,1-2H3,(H,25,26,27)
InChi Key DFQAJLQXPSPNJE-UHFFFAOYSA-N
Canonical SMILES Cn1c2ccccc2c(=O)n(c2cnc(nc12)Nc1ccc(cc1)N1CCC(CC1)O)C
Isomeric SMILES CN1C2=CC=CC=C2C(=O)N(C3=CN=C(N=C31)NC4=CC=C(C=C4)N5CCC(CC5)O)C
PubChem CID 54592204

Certificates

Certificate of Analysis(COA)

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Related Documents

 SDS

 Specification Sheet

References

1. Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N.  (2012)  Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen..  ACS Chem Biol,  7  (1): (185-96).  [PMID:21992004]

Solution Calculators

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