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XYT528B , CAS No.X614907, Agonist of GPBA receptor

Item Number

X614907

Grouped product items
SKU	Size	Availability	Price	Qty
X614907-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$560.90
X614907-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,500.90

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Basic Description

GPBAR1 Tchem G-protein coupled bile acid receptor 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C34H56O4/c1-9-10-27(35)38-26-15-16-31(6)24(30(26,4)5)14-17-33(8)25(31)12-11-23-28-22(21(2)3)13-18-34(28,29(36)37)20-19-32(23,33)7/h21-26,28H,9-20H2,1-8H3,(H,36,37)/t22-,23+,24?,25+,26+,28+,31-,32+,33+,34-/m0/s1
InChi Key	XQYINMZHVRUGDM-LSPHDCIISA-N
Canonical SMILES	C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2
PubChem CID	156587567

GPCRdb Ligand	XYT528B
PubChem CID	156587567

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1. Wang XY, Zhang SY, Li J, Liu HN, Xie X, Nan FJ. (2014) Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy.. Acta Pharmacol Sin, 35 (11): (1463-72). [PMID:25283506] [10.1021/op500134e]
2. Yun Y, Zhang C, Guo S, Liang X, Lan Y, Wang M, Zhuo N, Yin J, Liu H, Gu M et al.. (2021) Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5^H88Y Mutant Mice.. J Med Chem, 71 (13): (1755-70). [PMID:34406006] [10.1021/acs.jmedchem.1c00851]

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