Yatein - 99%, high purity , CAS No.40456-50-6

  • ≥99%
Item Number
Y650507
Grouped product items
SKUSizeAvailabilityPrice Qty
Y650507-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$280.90

Phenylpropanoids Lignans

Basic Description

Specifications & Purity≥99%
Biochemical and Physiological MechanismsYatein is a lignan isolated from A. chilensis , with antiproliferative activity. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression.
Storage TempProtected from light,Store at -80°C
Shipped InIce chest + Ice pads
Product Description

Yatein is a lignan isolated from A. chilensis , with antiproliferative activity Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression .

In Vitro

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells. Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells. Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cycle AnalysisCell Line: A549 cells, CL1-5 cells Concentration: 1.25 μM , 2.5 μM , 5 μM Incubation Time: 24 hours Result: Induced cell-cycle arrest at G2/M phase in both cell lines. Western Blot AnalysisCell Line: A549 cells, CL1-5 cells Concentration: 5 μM Incubation Time: 6 hours, 12 hours Result: Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.

In Vivo

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male NOD/SCID mice (6-8 weeks), with A549 cells xenograftDosage: 20 mg/kg Administration: Intraperitoneal injection, five times per week, for 42 days Result: Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.

Form:Oil

IC50& Target:HSV-1

Associated Targets(Human)

CYP3A4 Tclin Cytochrome P450 3A4 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ODC1 Tclin Ornithine decarboxylase (70 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ZR-75-1 (953 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Col2 (437 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-431 (6446 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lu1 (576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Artemia (698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Canonical SMILES COC1=CC(=CC(=C1OC)OC)C[C@@H]2[C@H](COC2=O)CC3=CC4=C(C=C3)OCO4
Isomeric SMILES COC1=CC(=CC(=C1OC)OC)C[C@@H]2[C@H](COC2=O)CC3=CC4=C(C=C3)OCO4
PubChem CID 442835
Molecular Weight 400.42

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

Solution Calculators