YC-1 - 98% , high purity , CAS No.170632-47-0, Activator of Guanylyl cyclase; α 1β 1;Activator of Guanylyl cyclase; α 2β 1

Item Number

Y274733

• Synonyms: 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole | A907557 | YC1 | yc-1 | [5-[1-(phenylmethyl)indazol-3-yl]furan-2-yl]methanol | GTPL5291 | KBio3_000654 | LIFICIGUAT [WHO-DD] | UNII-515CC1WPTE | IDI1_002079 | 1-Benzyl-3-(5'-hydroxymethyl-2-furyl)indazole |
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Reversible soluble guanylyl cyclase activator (EC 50 = 18.6 μM). NO-independent. Induces a concentration dependent increase in cGMP in vitro . Reduces blood-brain barrier permeability through HIF-1 inhibiton in vivo .
• Storage Temp: Store at -20°C,Desiccated
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: ACTIVATOR
• Mechanism of action: Activator of Guanylyl cyclase; α 1β 1;Activator of Guanylyl cyclase; α 2β 1
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:

to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs) to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.