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YK-4-279 - 10mM in DMSO, high purity , CAS No.1037184-44-3
Inhibitor of RNA helicase A (RHA)
Basic Description Synonyms YK-4-279 | 1037184-44-3 | 4,7-dichloro-3-hydroxy-3-(2-(4-methoxyphenyl)-2-oxoethyl)indolin-2-one | 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one | YK 4-279 | CHEMBL2011500 | 4,7-Dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoeth Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1. Inhibits Ewing's sarcoma family tumor (ESFT) cell growth; induces apoptosis. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description YK-4-279 is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA).
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 4,7-dichloro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-1H-indol-2-one INCHI InChI=1S/C17H13Cl2NO4/c1-24-10-4-2-9(3-5-10)13(21)8-17(23)14-11(18)6-7-12(19)15(14)20-16(17)22/h2-7,23H,8H2,1H3,(H,20,22) InChi Key HLXSCTYHLQHQDJ-UHFFFAOYSA-N Canonical SMILES COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O Isomeric SMILES COC1=CC=C(C=C1)C(=O)CC2(C3=C(C=CC(=C3NC2=O)Cl)Cl)O PubChem CID 44632017 Molecular Weight 366.2
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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