The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
YKL 06-061 - 10mM in DMSO, high purity , CAS No.2172617-15-9
Basic Description Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively. Storage Temp Protected from light,Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
YKL 06-061 YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.
Targets
SIK2 (Cell-free assay); SIK1 (Cell-free assay); SIK3 (Cell-free assay) 1.77 nM; 6.56 nM; 20.5 nM
Product Properties ALogP 5.541 HBD Count 1 Rotatable Bond 6
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-cyclobutyl-3-(2,6-dimethylphenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one INCHI InChI=1S/C30H37N7O2/c1-20-7-5-8-21(2)27(20)36-19-22-18-31-29(33-28(22)37(30(36)38)23-9-6-10-23)32-25-12-11-24(17-26(25)39-4)35-15-13-34(3)14-16-35/h5,7-8,11-12,17-18,23H,6,9-10,13-16,19H2,1-4H3,(H,31,32,33) InChi Key GVBAXIVNAHMIGH-UHFFFAOYSA-N Canonical SMILES CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC Isomeric SMILES CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCC4)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC PubChem CID 132992144 Molecular Weight 527.66
Chemical and Physical Properties Sensitivity light sensitive DMSO(mg / mL) Max Solubility 20 DMSO(mM) Max Solubility 37.9031952393587 Water(mg / mL) Max Solubility ＜1
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
