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YM 022 - ≥99%(HPLC), high purity , CAS No.145084-28-2, Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

Moligand™
≥99%(HPLC)

CAS#: 145084-28-2
Formula: C₃₂H₂₈N₄O₃
Molecular Weight: 516.6
EC Number: 803-039-9
PubChem CID: 122130

Item Number

Y286779

Grouped product items
SKU	Size	Availability	Price	Qty
Y286779-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$205.90
Y286779-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$842.90

Highly potent, selective non-peptide CCK2antagonist

View related series

CCK1 receptor Antagonist CCK2 receptor Antagonist

Basic Description

Synonyms	145084-28-2\|YM022\|YM-022\|YM 022\|UNII-772CP7W12N\|CHEMBL115121\|772CP7W12N\|3-(3-methylphenyl)-1-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea\|(R)-1-(2-Oxo-1-(2-oxo-2-(o-tolyl)ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4
Specifications & Purity	Moligand™, ≥99%(HPLC)
Biochemical and Physiological Mechanisms	Extremely potent and highly selective non-peptide CCK2silent antagonist (Kivalues are 68 pM and 63 nM at CCK2and CCK1receptors respectively). Actsin vivoto potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor

Associated Targets

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCKAR Tclin Cholecystokinin receptor type A 1 Activities

Discover Target: CCKAR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCKBR Tclin Gastrin/cholecystokinin type B receptor 1 Activities

Discover Target: CCKBR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor 0 Activities

Discover Target: TSHR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPT Tclin Microtubule-associated protein tau 0 Activities

Discover Target: MAPT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	1-(3-methylphenyl)-3-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea
INCHI	InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1
InChi Key	YCXFHPUBGMMWJQ-PMERELPUSA-N
Canonical SMILES	CC1=CC(=CC=C1)NC(=O)NC2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)CC(=O)C5=CC=CC=C5C
Isomeric SMILES	CC1=CC(=CC=C1)NC(=O)N[C@H]2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)CC(=O)C5=CC=CC=C5C
WGK Germany	3
Alternate CAS	145084-28-2
PubChem CID	122130
MeSH Entry Terms	1-(2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-3-(3-methylphenyl)urea;YM 022;YM-022;YM022
Molecular Weight	516.6

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H301:Toxic if swallowed
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately.
WGK Germany	3
RIDADR	UN28116.1/PGIII

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