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YM 022 - ≥99%(HPLC), high purity , CAS No.145084-28-2, Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor
Highly potent, selective non-peptide CCK2antagonist
Basic Description
| Synonyms | DTXSID40932492 | SCHEMBL2870373 | r-1-(2,3-dihydro-1-(2-methylphenacyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepin-3-yl)-3(3-methylphenyl)urea | HY-103355 | Q27089258 | AKOS027378207 | YCXFHPUBGMMWJQ-PMERELPUSA-N | (R)-N-[2,3-DIHYDRO-1-[2-(2-METHYLPHENYL)-2-OXOE |
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| Specifications & Purity | Moligand™, ≥99%(HPLC) |
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| Biochemical and Physiological Mechanisms | Extremely potent and highly selective non-peptide CCK2silent antagonist (Kivalues are 68 pM and 63 nM at CCK2and CCK1receptors respectively). Actsin vivoto potently inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation with |
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| Storage Temp | Room temperature |
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| Shipped In | Normal |
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| Grade | Moligand™ |
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| Action Type | ANTAGONIST |
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| Mechanism of action | Antagonist of CCK 1 receptor;Antagonist of CCK 2 receptor |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 1-(3-methylphenyl)-3-[(3R)-1-[2-(2-methylphenyl)-2-oxoethyl]-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl]urea |
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| INCHI | InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1 |
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| InChi Key | YCXFHPUBGMMWJQ-PMERELPUSA-N |
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| Canonical SMILES | CC1=CC(=CC=C1)NC(=O)NC2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)CC(=O)C5=CC=CC=C5C |
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| Isomeric SMILES | CC1=CC(=CC=C1)NC(=O)N[C@H]2C(=O)N(C3=CC=CC=C3C(=N2)C4=CC=CC=C4)CC(=O)C5=CC=CC=C5C |
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| WGK Germany | 3 |
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| Alternate CAS | 145084-28-2 |
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| PubChem CID | 122130 |
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| MeSH Entry Terms | 1-(2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-3-(3-methylphenyl)urea;YM 022;YM-022;YM022 |
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| Molecular Weight | 516.6 |
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Chemical and Physical Properties
| Solubility | Solvent:DMSO, Max Conc. mg/mL: 51.66, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 5.17, Max Conc. mM: 10 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06 |
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| Signal | Danger |
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| Hazard Statements | H301:Toxic if swallowed |
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| Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
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| WGK Germany | 3 |
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| RIDADR | UN28116.1/PGIII |
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