Potent, selective, water-soluble, non-competitive mGlu 1 antagonist (IC 50 = 16 nM) Selective over mGlu 2 , 3 , 4 , 5 , 6 , and 7 and ionotropic receptors (IC 50 > 10 μM). Orally active analgesic in vivo . Also available in simple stock solutions ( ab1466
Storage Temp
Store at 2-8°C,Desiccated
Shipped In
Wet ice
Grade
Moligand™
Action Type
ALLOSTERIC MODULATOR
Mechanism of action
Allosteric modulator of mGlu 1 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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2.Zhang L & Alger BE. (2010) Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome.. J Neurosci, 30 (16):(5724-9). [PMID:20410124]
3.Jo J et al.. (2010) Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95.. Nat Neurosci, 13 (10):(1216-24). [PMID:20852624]
4.Lafourcade CA et al.. (2009) Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG.. PLoS One, 4 (7):(e6122). [PMID:19568435]
5.Biever A et al.. (2015) PKA-dependent phosphorylation of ribosomal protein S6 does not correlate with translation efficiency in striatonigral and striatopallidal medium-sized spiny neurons.. J Neurosci, 35 (10):(4113-30). [PMID:25762659]
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