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YS121 - A solution in methyl acetate, high purity , CAS No.916482-17-2
an inhibitor of mPGES-1, 5-LO, Cox-1, and Cox-2
Basic Description Synonyms YS121 | 916482-17-2 | YS-121 | YS 121 | 2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl}sulfanyl)octanoic acid | CHEMBL518038 | GTPL5293 | BDBM24560 | DTXSID00647434 | CHEBI:184083 | Pirinixic acid-based compound, 6a | 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin- Specifications & Purity Moligand™, A solution in methyl acetate Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Product Description YS121 is a dual inhibitor of mPGES-1 (IC|50|= 3.9 μM) and 5-LO (IC|50|= 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS121 has minor effects on Cox-1 and Cox-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[4-chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoic acid INCHI InChI=1S/C20H26ClN3O2S/c1-4-5-6-7-11-16(19(25)26)27-20-23-17(21)12-18(24-20)22-15-10-8-9-13(2)14(15)3/h8-10,12,16H,4-7,11H2,1-3H3,(H,25,26)(H,22,23,24) InChi Key HVJBWTVMRIOTEL-UHFFFAOYSA-N Canonical SMILES CCCCCCC(C(=O)O)SC1=NC(=CC(=N1)Cl)NC2=CC=CC(=C2C)C Isomeric SMILES CCCCCCC(C(=O)O)SC1=NC(=CC(=N1)Cl)NC2=CC=CC(=C2C)C PubChem CID 24816385 Molecular Weight 408
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