Z 944 - ≥98%(HPLC), high purity , CAS No.1199236-64-0, Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Item Number

Z288507

• Synonyms: 4-(((3-Chloro-5-fluorobenzoyl)amino)methyl)-N-(1,1-dimethylethyl)-1-piperidineacetamide | PRAX944 | PRAX-944 | PTFE rod, 3.18mm (0.125in) dia | BDBM50192689 | CS-0078307 | 1199236-64-0 | 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Selective T-type Ca2+channel blocker (IC50values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: CHANNEL BLOCKER
• Mechanism of action: Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Product Description

Product Introduction

Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.