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Z 944 - ≥98%(HPLC), high purity , CAS No.1199236-64-0, Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3

Moligand™

≥98%(HPLC)

CAS#: 1199236-64-0
Formula: C₁₉H₂₇ClFN₃O₂
Molecular Weight: 383.89
PubChem CID: 44540045

Item Number

Z288507

Grouped product items
SKU	Size	Availability	Price
Z288507-5mg	5mg	In stock	$137.90
Z288507-10mg	10mg	In stock	$226.90
Z288507-25mg	25mg	In stock	$503.90
Z288507-50mg	50mg	In stock	$939.90
Z288507-100mg	100mg	In stock	$1,583.90

CaV3.x blocker

View related series

Cav3.1 Channel blocker Cav3.2 Channel blocker Cav3.3 Channel blocker

Basic Description

Synonyms	4-(((3-Chloro-5-fluorobenzoyl)amino)methyl)-N-(1,1-dimethylethyl)-1-piperidineacetamide \| PRAX944 \| PRAX-944 \| PTFE rod, 3.18mm (0.125in) dia \| BDBM50192689 \| CS-0078307 \| 1199236-64-0 \| 4-[[(3-Chloro-5-fluorobenzoyl)amino)methyl]-N-(1,1-dimethylethyl)-1-
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective T-type Ca2+channel blocker (IC50values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3
Product Description	Product Introduction Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.

Associated Targets(Human)

CACNA1H Tclin Voltage-dependent T-type calcium channel subunit alpha-1H (3 Activities)

Discover Target: CACNA1H

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1G Tclin Voltage-dependent T-type calcium channel subunit alpha-1G (3 Activities)

Discover Target: CACNA1G

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1I Tclin Voltage-dependent T-type calcium channel subunit alpha-1I (3 Activities)

Discover Target: CACNA1I

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1H Tclin Voltage-gated T-type calcium channel alpha-1H subunit (1913 Activities)

Discover Target: CACNA1H

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cacna1g Voltage-gated T-type calcium channel alpha-1G subunit (1 Activities)

Discover Target: Cacna1g

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cacna1i Voltage-gated T-type calcium channel alpha-1I subunit (2 Activities)

Discover Target: Cacna1i

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide
INCHI	InChI=1S/C19H27ClFN3O2/c1-19(2,3)23-17(25)12-24-6-4-13(5-7-24)11-22-18(26)14-8-15(20)10-16(21)9-14/h8-10,13H,4-7,11-12H2,1-3H3,(H,22,26)(H,23,25)
InChi Key	JOCLITFYIMJMNK-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F
Isomeric SMILES	CC(C)(C)NC(=O)CN1CCC(CC1)CNC(=O)C2=CC(=CC(=C2)Cl)F
PubChem CID	44540045
Molecular Weight	383.89

PubChem CID

44540045

CAS Registry No.

1199236-64-0

RCSB PDB Ligand

DZR

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
I2222239	Certificate of Analysis	Jul 13, 2022	Z288507
I2222240	Certificate of Analysis	Jul 13, 2022	Z288507
I2222241	Certificate of Analysis	Jul 13, 2022	Z288507
I2222242	Certificate of Analysis	Jul 13, 2022	Z288507
I2222243	Certificate of Analysis	Jul 13, 2022	Z288507

Solubility

Solvent:DMSO, Max Conc. mg/mL: 38.39, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.39, Max Conc. mM: 100

Melt Point(°C)

122-124°C

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