Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z302772-1mg | 1mg | In stock | $64.90 | |
Z302772-5mg | 5mg | In stock | $176.90 | |
Z302772-10mg | 10mg | In stock | $295.90 | |
Z302772-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $666.90 |
Cell permeable caspase-3 inhibitor
Synonyms | N-benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl-ketone | SCHEMBL18328791 | L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester | Z-Asp(O-Me |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | A potent, cell-permeable, and irreversible inhibitor of caspase-3. Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10. Once in the cell, endogenous esterase activity hydrolyzes the methyl groups to form the biologically active form. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product introduction Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-4-methoxy-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]-5-oxopentanoate |
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INCHI | InChI=1S/C30H41FN4O12/c1-17(2)26(29(42)33-20(22(36)15-31)13-24(38)45-4)35-27(40)19(11-12-23(37)44-3)32-28(41)21(14-25(39)46-5)34-30(43)47-16-18-9-7-6-8-10-18/h6-10,17,19-21,26H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t19-,20-,21-,26-/m0/s1 |
InChi Key | GBJVAVGBSGRRKN-JYEBCORGSA-N |
Canonical SMILES | CC(C)C(C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CCC(=O)OC)NC(=O)C(CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
Isomeric SMILES | CC(C)[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](CCC(=O)OC)NC(=O)[C@H](CC(=O)OC)NC(=O)OCC1=CC=CC=C1 |
PubChem CID | 16760394 |
Molecular Weight | 668.66 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2423350 | Certificate of Analysis | Aug 15, 2024 | Z302772 |
H2423353 | Certificate of Analysis | Aug 15, 2024 | Z302772 |
H2423355 | Certificate of Analysis | Aug 15, 2024 | Z302772 |
H2423358 | Certificate of Analysis | Aug 15, 2024 | Z302772 |
H2423360 | Certificate of Analysis | Aug 15, 2024 | Z302772 |
C2306441 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
C2306445 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
C2306446 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
C2306447 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
C2401077 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
C2427089 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
L2327024 | Certificate of Analysis | Nov 11, 2022 | Z302772 |
Solubility | insoluble in H2O; insoluble in EtOH; ≥60 mg/mL in DMSO |
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Starting at $241.90
1. Fan Zhang, Changqing Mao, Siyu Cao, Runchi Zhang, Yi Guo, Guifang Chen, Chang Feng. (2022) A peptide-DNA hybrid bio-nanomicelle and its application for detection of caspase-3 activity. Frontiers in Chemistry, 10 (1005315). [PMID:36147255] [10.3389/fchem.2022.1005315] |
1. De D et al.. (2019) Ethanolic extract of leaf of Dillenia pentagyna reduces in-vitro cell migration and induces intrinsic pathway of apoptosis via downregulation of NF-?ß in human NSCLC A549 cells.. J Cell Biochem, 120 (12): (19841-19857). [PMID:31318086] |
2. Yang H et al.. (2019) Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways.. World J Gastrointest Oncol, 11 (5): (377-392). [PMID:31139308] |
3. Fan Zhang, Changqing Mao, Siyu Cao, Runchi Zhang, Yi Guo, Guifang Chen, Chang Feng. (2022) A peptide-DNA hybrid bio-nanomicelle and its application for detection of caspase-3 activity. Frontiers in Chemistry, 10 (1005315). [PMID:36147255] [10.3389/fchem.2022.1005315] |