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Z-Guggulsterone - >98%, high purity , CAS No.39025-23-5
Broad spectrum steroid receptor ligand. More active isomer ofguggulsterone(Cat. No. 2013)
Basic Description Synonyms AVQFHKYAVVQYQO-UHFFFAOYSA- | 6CST3U34GN | GUGGULSTERONE Z [USP-RS] | NCGC00260067-01 | Z/E-Guggulsterone | AC-28813 | CHEBI:135338 | Guggulsterones Z | 2-(2-Aminothiazol-3(2H)-yl)-1-phenylethanone | Guggulsterone | AC-6215 | Q27264514 | (17Z)-Guggulsteron Specifications & Purity ≥98% Biochemical and Physiological Mechanisms Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Kivalues are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki= 315 nM). Induces apoptosis in prostate cancer cells and i Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione INCHI InChI=1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1 InChi Key WDXRGPWQVHZTQJ-OSJVMJFVSA-N Canonical SMILES CC=C1C(=O)CC2C1(CCC3C2CCC4=CC(=O)CCC34C)C Isomeric SMILES C/C=C/1\C(=O)C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C WGK Germany 3 PubChem CID 6450278 Molecular Weight 312.45
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 6.25, Max Conc. mM: 20 with gentle warming; Solvent:ethanol, Max Conc. mg/mL: 3.12, Max Conc. mM: 10 with gentle warming
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P264: Wash hands [and …] thoroughly after handling.
P362+P364: Take off contaminated clothing and wash it before reuse.
P332+P317: If skin irritation occurs: Get medical help.
WGK Germany 3
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