Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Basic Description
| Synonyms | 1,2-Pyrrolidinedicarboxylic acid, 1-benzyl ester, L- | 1-Benzyloxycarbonyl-L-proline | CBZ-L-PRO-OH | MFCD00003170 | N-(BENZYLOXYCARBONYL)-(S)-PROLINE | N-[(phenyl-methoxy)carbonyl]-L-proline | N-Carbobenzoxy-L-proline | N-carbobenzoxyproline | 1-Carboben |
|---|---|
| Specifications & Purity | ≥98% |
| Shipped In | Normal |
Associated Targets(non-human)
Ehrlich (1318 Activities)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488187285 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187285 |
| IUPAC Name | (2S)-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid |
| INCHI | InChI=1S/C13H15NO4/c15-12(16)11-7-4-8-14(11)13(17)18-9-10-5-2-1-3-6-10/h1-3,5-6,11H,4,7-9H2,(H,15,16)/t11-/m0/s1 |
| InChi Key | JXGVXCZADZNAMJ-NSHDSACASA-N |
| Canonical SMILES | C1CC(N(C1)C(=O)OCC2=CC=CC=C2)C(=O)O |
| Isomeric SMILES | C1C[C@H](N(C1)C(=O)OCC2=CC=CC=C2)C(=O)O |
| WGK Germany | 3 |
| RTECS | UY0745000 |
| PubChem CID | 101987 |
| Molecular Weight | 249.26 |
| Beilstein | 88579 |
| Reaxy-Rn | 88579 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 F23251235 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251239 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251253 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251257 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251260 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251274 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251277 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251278 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251284 | Certificate of Analysis | May 11, 2023 | Z105461 |
| F23251285 | Certificate of Analysis | May 11, 2023 | Z105461 |
| C1915125 | Certificate of Analysis | Jan 06, 2023 | Z105461 |
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Chemical and Physical Properties
| Specific Rotation[α] | -40 ° (C=2, EtOH) |
|---|---|
| Melt Point(°C) | 75-77°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H318:Causes serious eye damage H317:May cause an allergic skin reaction |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | UY0745000 |
| Reaxy-Rn | 88579 |
Related Documents
References
| 1. M Dolenga,P Hechtman. (1992-05-01) Cytotoxicity of carbobenzoxy-protected amino acids.. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 28A ((5)): (300-302). [PMID:1597402] |
| 2. Sachin Mittal,Xueqin Song,Balvinder S Vig,Gordon L Amidon. (2007-03-23) Proline prodrug of melphalan targeted to prolidase, a prodrug activating enzyme overexpressed in melanoma.. Pharmaceutical research, 24 ((7)): (1290-1298). [PMID:17377743] |
| 3. Arkadiusz Surazynski,Wojciech Miltyk,Izabela Prokop,Jerzy Palka. (2010-09-28) Prolidase-dependent regulation of TGF β (corrected) and TGF β receptor expressions in human skin fibroblasts.. European journal of pharmacology, 649 ((1-3)): (115-119). [PMID:20868675] |
| 4. Marie O Pohl,Thomas O Edinger,Silke Stertz. (2014-07-18) Prolidase is required for early trafficking events during influenza A virus entry.. Journal of virology, 88 ((19)): (11271-11283). [PMID:25031340] |
| 5. Binah Baht Ysrayl,Muthukumar Balasubramaniam,Ife Albert,Fernando Villalta,Jui Pandhare,Chandravanu Dash. (2019-02-24) A Novel Role of Prolidase in Cocaine-Mediated Breach in the Barrier of Brain Microvascular Endothelial Cells.. Scientific reports, 9 ((1)): (2567-2567). [PMID:30796241] |
| 6. Anna Lupi,Antonio Rossi,Patrizia Vaghi,Angelo Gallanti,Giuseppe Cetta,Antonella Forlino. (2005-05-10) N-benzyloxycarbonyl-L-proline: an in vitro and in vivo inhibitor of prolidase.. Biochimica et biophysica acta, 1744 ((2)): (157-163). [PMID:15878628] |