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Z-VAD(OMe)-FMK - 98%, high purity , CAS No.187389-52-2

  • ≥98%
Item Number
V275259
Grouped product items
SKUSizeAvailabilityPrice Qty
V275259-1mg
1mg
In stock
$246.90
V275259-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,107.90
V275259-10mg
10mg
In stock
$1,993.90
V275259-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$4,484.90
V275259-50mg
50mg
In stock
$8,071.90
V275259-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$14,529.90

Discover Z-VAD(OMe)-FMK by Aladdin Scientific in 98% for only $246.90. Available - in Ligands at Aladdin Scientific. Cell permeable, irreversible pan-caspase inhibitor Tags: .

Basic Description

Synonyms187389-52-2|Z-VAD(OMe)-FMK|Z-Val-Ala-Asp(OMe)-FMK|pan-caspase inhibitor|C22H30FN3O7|ZVAD-FMK|5-Bromo-2 -deoxyuridine|Z-Val-Ala-Asp(OMe)-fluoromethyl ketone|Z-Val-Ala-Asp(OMe)-CH2F|methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylami
Specifications & Purity98%
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
Product Description

Product Application:
Z-VAD-FMK has been used: to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells to induce autophagy in Jurkat and K562 cells to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Names and Identifiers

IUPAC Name methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoate
INCHI InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
InChi Key MIFGOLAMNLSLGH-QOKNQOGYSA-N
Canonical SMILES CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1
PubChem CID 5497174
Molecular Weight 467.49

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Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
K2302103Certificate of AnalysisAug 22, 2024 V275259
G2321148Certificate of AnalysisMay 22, 2024 V275259
A2212152Certificate of AnalysisJul 12, 2023 V275259
A2212493Certificate of AnalysisOct 21, 2022 V275259
A2212495Certificate of AnalysisOct 21, 2022 V275259
A2212496Certificate of AnalysisOct 21, 2022 V275259
A2212498Certificate of AnalysisOct 21, 2022 V275259
A2212497Certificate of AnalysisDec 24, 2021 V275259

Chemical and Physical Properties

SolubilitySoluble in DMSO to 20 mM

Related Documents

References

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11. Jaru-Ampornpan P et al..  (2017)  Porcine Epidemic Diarrhea Virus 3C-Like Protease-Mediated Nucleocapsid Processing: Possible Link to Viral Cell Culture Adaptability..  J Virol,  91  (2):   [PMID:27807240]
12. Gain C et al..  (2020)  Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway..  PLoS Pathog,  16  (2): (e1008105).  [PMID:32092124]
13. Nishi K et al..  (2017)  ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line..  Cell Death Dis,  (12): (3218).  [PMID:29242562]
14. Lemke J et al..  (2014)  Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1..  Cell Death Differ,  21  (3): (491-502).  [PMID:24362439]
15. Onofre J et al..  (2020)  Testicular tissue cryopreservation is the preferred method to preserve spermatogonial stem cells prior to transplantation..  Reprod Biomed Online,  40  (2): (261-269).  [PMID:32001160]
16. Qian L et al..  (2016)  Two-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models..  Sci Rep,  (26385).  [PMID:27210613]
17. Onofre J et al..  (2018)  What is the best protocol to cryopreserve immature mouse testicular cell suspensions?.  Reprod Biomed Online,  37  (6-17).  [PMID:29776850]

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