zidesamtinib , CAS No.Z614962, Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

Item Number

Z614962

Grouped product items
SKU	Size	Availability	Price	Qty
Z614962-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
Z614962-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,390.90

View related series

Basic Description

Synonyms	Example 5 [US383715659] \| SCHEMBL24007115 \| EX-A8016 \| NVL520 \| NVL-520 \| 2739829-00-4 \| MX5KQV5XHC \| Zidesamtinib \| zidesamtinib [INN] \| GTPL12392
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of c-ros oncogene 1; receptor tyrosine kinase;Inhibitor of neurotrophic receptor tyrosine kinase 1

Associated Targets(Human)

ROS1 Tclin Proto-oncogene tyrosine-protein kinase ROS (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1
InChi Key	DTWUUAFTYSMNQX-GFCCVEGCSA-N
Canonical SMILES	CCN1N=CC2=C1C3=CC(O[C@H](C)C4=CC(F)=CC=C4C5=NN(C)N=C5C2)=C(N)N=C3
Isomeric SMILES	CCN1C2=C(CC3=NN(N=C3C4=C(C=C(C=C4)F)[C@H](OC5=C(N=CC2=C5)N)C)C)C=N1
PubChem CID	166560233

References

1. Drilon A, Horan JC, Tangpeerachaikul A, Besse B, Ou SI, Gadgeel SM, Camidge DR, van der Wekken AJ, Nguyen-Phuong L, Acker A et al.. (2022) NVL-520 is a selective, TRK-sparing, and brain-penetrant inhibitor of ROS1 fusions and secondary resistance mutations.. Cancer Discov, 71 (13): (1755-70). [PMID:36511802] [10.1021/op500134e]

Solution Calculators

Determine the necessary mass, volume, or concentration for preparing a solution.

Determine the dilution needed to prepare a stock solution.

Basic Description