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Zacopride hydrochloride - 97%, high purity , CAS No.101303-98-4
Highly potent 5-HT3antagonist; also 5-HT4agonist
Basic Description Synonyms HY-103137 | Q27274695 | (+/-)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride | 4-amino-n-1-azabicyclo[2,2,2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride | BEA30398 | DTXCID2025686 | MS-25317 | SR-01000597764-1 | Zaco Specifications & Purity ≥97% Biochemical and Physiological Mechanisms Highly potent 5-HT3receptor antagonist (Ki= 0.38 nM) and 5-HT4receptor agonist (Ki= 373 nM). Antiemetic and anxiolytic following systemic administrationin vivo. Storage Temp Store at 2-8°C,Desiccated Shipped In Wet ice Product Description Product description
Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist with Kis of 0.38 and 373 nM for 5-HT3 and 5-HT4 receptor, respectively. Zacopride hydrochloride is also a moderate IK1 channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects。
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488196440 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196440 IUPAC Name 4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide;hydrochloride INCHI InChI=1S/C15H20ClN3O2.ClH/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H InChi Key ITXVOUSORXSTQH-UHFFFAOYSA-N Canonical SMILES COC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N.Cl Isomeric SMILES COC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N.Cl PubChem CID 9928181 Molecular Weight 346.26
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 34.63, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 34.62, Max Conc. mM: 100 Sensitivity Moisture sensitive
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D2308665