Zafirlukast - ≥99%, high purity , Cysteinyl leukotriene receptor 1 antagonist, CAS No.107753-78-6, Cysteinyl leukotriene receptor 1 antagonist

Item Number

Z129979

• Synonyms: SR-01000759386-9 | ZAFIRLUKAST [MI] | AB00639922_09 | cyclopentyl N-[3-[[2-methoxy-4-(o-tolylsulfonylcarbamoyl)phenyl]methyl]-1-methyl-indol-5-yl]carbamate | Q-201940 | Tox21_112176_1 | Z0029 | ZAFIRLUKAST [JAN] | SR-01000759386-5 | BDBM50009073 | ICI 204
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. The cysteinyl-leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, au
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST, ANTAGONIST, INHIBITOR
• Mechanism of action: Cysteinyl leukotriene receptor 1 antagonist
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Zafirlukast is a leukotriene receptor antagonist (LTRA). (IC50=0.6μM, IC50=7.0 μM for CYP2C9).
A potent and selective CysLT1 receptor antagonist.

Product description：

Zafirlukast is a potent leukotriene D4 (LTD4) receptor antagonist with oral activity. Zafirlukast has antiasthmatic, anti-inflammatory and antibacterial effects

Application：

Zafirlukast has been used to stimulate pancreatic β cell line (MIN6) and pancreatic islets for insulin secretion assay. It may be used as an adenosine triphosphate-binding cassette transporter (ABCG2) inhibitor in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cytotoxicity assay in human embryonic kidney cells (HEK293) and in Kirby-Bauer disc diffusion assays, bactericidal activity and minimal inhibitory concentration (mIC) assay against M. smegmatis