Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Z124915-25mg | 25mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $98.90 | |
Z124915-100mg | 100mg | In stock | $326.90 | |
Z124915-250mg | 250mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $735.90 | |
Z124915-1g | 1g | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $2,648.90 |
Antiviral. Neuraminidase inhibitor
Synonyms | GANA | J05AH01 | UNII-L6O3XI777I | Z0023 | (2R,3R,4S)-3-(acetylamino)-4-carbamimidamido-2-((1R,2R)-1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid | 4-guanidino-2,4-dideoxy-2,3-didehydro-N-acetylneuraminic acid | Zanamivir (Relenza) | (2R,3 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Zanamivir is an influenza viral neuraminidase inhibitor that is a structural analog of the sialic acid.Antiviral. Neuraminidase inhibitor. Binds active site of neuraminidase protein, preventing influenza virus escape from host. Inhibitor of virus replicat |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Neuraminidase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus. |
ALogP | -3.2 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488183409 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183409 |
IUPAC Name | (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid |
INCHI | InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1 |
InChi Key | ARAIBEBZBOPLMB-UFGQHTETSA-N |
Canonical SMILES | CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N |
Isomeric SMILES | CC(=O)N[C@@H]1[C@H](C=C(O[C@H]1[C@@H]([C@@H](CO)O)O)C(=O)O)N=C(N)N |
WGK Germany | 3 |
RTECS | RA9451000 |
PubChem CID | 60855 |
Molecular Weight | 332.31 |
PubChem CID | 60855 |
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CAS Registry No. | 139110-80-8 |
ChEMBL Ligand | CHEMBL222813 |
BindingDB Ligand | 4934 |
DrugBank Ligand | DB00558 |
RCSB PDB Ligand | ZMR |
PubChem SID | 488183409 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2312821 | Certificate of Analysis | Apr 23, 2023 | Z124915 |
D2312860 | Certificate of Analysis | Apr 23, 2023 | Z124915 |
D2312852 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
D2312853 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
D2312856 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
D2312854 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
D2312857 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
D2312865 | Certificate of Analysis | Apr 21, 2023 | Z124915 |
E1520088 | Certificate of Analysis | Jan 17, 2023 | Z124915 |
Solubility | Soluble in Water、DMSO |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | RA9451000 |
1. Jianyu Zhu, Qiang Li, Xuezhi Yu, Xiya Zhang, Hongfang Li, Kai Wen, Yuebin Ke, Suxia Zhang, Zhanhui Wang. (2021) Synthesis of hapten, production of monoclonal antibody, and development of immunoassay for ribavirin detection in chicken. JOURNAL OF FOOD SCIENCE, 86 (7): (2851-2860). [PMID:34146404] [10.1111/1750-3841.15789] |
2. Zhaopeng Wang, Xuezhi Yu, Licai Ma, Hebing Liu, Shuangyang Ding, Zhanhui Wang, Xiya Zhang, Jianzhong Shen, Kai Wen. (2018) Preparation of high affinity antibody for ribavirin with new haptens and residue analysis in chicken muscle, eggs and duck muscle. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 35 (7): (1247-1256). [PMID:29578378] [10.1080/19440049.2018.1447693] |
1. Krueger AC, Xu Y, Kati WM, Kempf DJ, Maring CJ, McDaniel KF, Molla A, Montgomery D, Kohlbrenner WE. (2008) Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.. Bioorg Med Chem Lett, 18 (5): (1692-5). [PMID:18242993] [10.1021/op500134e] |
2. Wen WH, Wang SY, Tsai KC, Cheng YS, Yang AS, Fang JM, Wong CH. (2010) Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses.. Bioorg Med Chem, 18 (11): (4074-84). [PMID:20452227] [10.1021/op500134e] |
3. Richards MR, Guo T, Hunter CD, Cairo CW. (2018) Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.. Bioorg Med Chem, 26 (19): (5349-5358). [PMID:29903413] [10.1021/op500134e] |
4. de Oliveira Formiga R, Amaral FC, Souza CF, Mendes DAGB, Wanderley CWS, Lorenzini CB, Santos AA, Antônia J, Faria LF, Natale CC et al.. (2022) Neuraminidase is a host-directed approach to regulate neutrophil responses in sepsis and COVID-19.. Br J Pharmacol, 71 (13): (1755-70). [PMID:36526272] [10.1111/bph.16013] |
5. Jianyu Zhu, Qiang Li, Xuezhi Yu, Xiya Zhang, Hongfang Li, Kai Wen, Yuebin Ke, Suxia Zhang, Zhanhui Wang. (2021) Synthesis of hapten, production of monoclonal antibody, and development of immunoassay for ribavirin detection in chicken. JOURNAL OF FOOD SCIENCE, 86 (7): (2851-2860). [PMID:34146404] [10.1111/1750-3841.15789] |
6. Zhaopeng Wang, Xuezhi Yu, Licai Ma, Hebing Liu, Shuangyang Ding, Zhanhui Wang, Xiya Zhang, Jianzhong Shen, Kai Wen. (2018) Preparation of high affinity antibody for ribavirin with new haptens and residue analysis in chicken muscle, eggs and duck muscle. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment, 35 (7): (1247-1256). [PMID:29578378] [10.1080/19440049.2018.1447693] |